Détail du document
Identifiant
doi:10.1038/s41416-022-01961-w...
Auteur
Huang, Xiwen Hansen, Johnni Lee, Pei-Chen Wu, Chia-Kai Federman, Noah Arah, Onyebuchi A. Li, Chung-Yi Olsen, Jorn Ritz, Beate Heck, Julia E.Langue
enEditeur
Nature
Catégorie
Epidemiology
Année
2022
Date de référencement
14/09/2022
Mots clés
0 denmark taiwan risk childhood ci 95% gestational cancer diabetes maternalRésumé
Background The effect of maternal diabetes on childhood cancer has not been widely studied.
Methods We examined this in two population-based studies in Denmark ( N = 6420 cancer cases, 160,484 controls) and Taiwan ( N = 2160 cancer cases, 2,076,877 non-cases) using logistic regression and Cox proportional hazard regression adjusted for birth year, child’s sex, maternal age and birth order.
Results Gestational diabetes in Denmark [odds ratio (OR) = 0.98, 95% confidence interval (CI): 0.71–1.35] or type II and gestational diabetes in Taiwan (type II: hazard ratio (HR) = 0.81, 95% CI: 0.63–1.05; gestational diabetes: HR = 1.06, 95% CI: 0.92–1.22) were not associated with cancer (all types combined).
In Denmark, maternal type I diabetes was associated with the risk of glioma (OR = 2.33, 95% CI: 1.04–5.22), while in Taiwan, the risks of glioma (HR = 1.59, 95% CI: 1.01–2.50) were elevated among children whose mothers had gestational diabetes.
There was a twofold increased risk for hepatoblastoma with maternal type II diabetes (HR = 2.02, 95% CI: 1.02–4.00).
Conclusions Our results suggest that maternal diabetes is an important risk factor for certain types of childhood cancers, emphasising the need for effective interventions targeting maternal diabetes to prevent serious health effects in offspring.
Huang, Xiwen,Hansen, Johnni,Lee, Pei-Chen,Wu, Chia-Kai,Federman, Noah,Arah, Onyebuchi A.,Li, Chung-Yi,Olsen, Jorn,Ritz, Beate,Heck, Julia E., 2022, Maternal diabetes and childhood cancer risks in offspring: two population-based studies, Nature
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