Détail du document
Identifiant
doi:10.1038/s41598-025-89080-3...
Auteur
Peters, Tracy L. Qiu, Weihong Yang, Haomin Huang, Wuqing Hu, Yizhen Zou, Zhangyu Ye, WeiminLangue
enEditeur
Nature
Catégorie
Epidemiology
Année
2025
Date de référencement
12/02/2025
Mots clés
amyotrophic lateral sclerosis epidemiology frailty cachexia study associationsRésumé
In the present study, we investigated the associations of cachexia (loss of muscle, weight and fat) and frailty (loss of weight and muscle) status with the risk of developing amyotrophic lateral sclerosis, because these specific terms are rarely used in this research area.
In this prospective study, we extracted cachexia and frailty status from the UK Biobank cohort to study the associations of these conditions (as determined via international classification of disease-10 codes) with amyotrophic lateral sclerosis.
There was a greater risk of developing amyotrophic lateral sclerosis among individuals with cachexia and frailty status after adjusting for age, sex, income (pounds), body mass index, UK Biobank centers and smoking status.
Among individuals with frailty status: a grip strength of < 21 kg, a slow walking speed, and exhaustion (more than half the days or nearly every day) increase the risk of developing amyotrophic lateral sclerosis.
We believe that studying cachexia and frailty status can be used to help define and treat amyotrophic lateral sclerosis.
Peters, Tracy L.,Qiu, Weihong,Yang, Haomin,Huang, Wuqing,Hu, Yizhen,Zou, Zhangyu,Ye, Weimin, 2025, Associations of cachexia and frailty with amyotrophic lateral sclerosis, Nature
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