Détail du document
Identifiant
doi:10.1007/s00775-024-02055-z...
Auteur
Messaoudi, Hiba Yaşa Atmaca, Göknur Türkkol, Ayşegül Bilgin, Mehmet Dinçer Erdoğmuş, AliLangue
enEditeur
Springer
Catégorie
Life Sciences
Année
2024
Date de référencement
15/05/2024
Mots clés
sono-photodynamic therapy singlet oxygen prostate cancer pc3 cell line oxygen synthesized studies singlet 0 prostate cancerRésumé
This study demonstrates the potential of sono-photodynamic therapy as an effective approach for enhancing singlet oxygen generation using the synthesized Schiff-base diaxially substituted silicon phthalocyanines.
In photochemical studies, the singlet oxygen quantum yields ( Φ _ ∆ ) were determined as 0.43 for Si1a , 0.94 for Q-Si1a , 0.58 for S-Si1a , and 0.49 for B-Sia1 .
In sono-photochemical studies, the Φ_∆ values were reached to 0.67 for Si1a , 1.06 for Q-Si1a , 0.65 for S-Si1a , and 0.67 for B-Sia1 .
In addition, this study demonstrates the therapeutic efficacy of phthalocyanines synthesized as sensitizers on the PC3 prostate cancer cell line through in vitro experiments.
The application of these treatment modalities exhibited notable outcomes, leading to a substantial decrease in cell viability within the PC3 prostate cancer cell line.
These findings highlight the potential of utilizing these synthesized phthalocyanines as promising therapeutic agents for prostate cancer treatment.
Graphical Abstract
Messaoudi, Hiba,Yaşa Atmaca, Göknur,Türkkol, Ayşegül,Bilgin, Mehmet Dinçer,Erdoğmuş, Ali, 2024, Monitoring of singlet oxygen generation of a novel Schiff-base substituted silicon phthalocyanines by sono-photochemical studies and in vitro activities on prostate cancer cell, Springer
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