Détail du document
Identifiant
doi:10.1038/s42003-023-05408-7...
Auteur
Li, Jialin Tang, Mingbo Gao, Xinliang Tian, Suyan Liu, WeiLangue
enEditeur
Nature
Catégorie
Life Sciences
Année
2023
Date de référencement
11/10/2023
Mots clés
analysis risk levels cathepsin lung cancer mendelian randomizationRésumé
Lung cancer, a major contributor to cancer-related fatalities worldwide, involves a complex pathogenesis.
Cathepsins, lysosomal cysteine proteases, play roles in various physiological and pathological processes, including tumorigenesis.
Observational studies have suggested an association between cathepsins and lung cancer.
However, the causal link between the cathepsin family and lung cancer remains undetermined.
This study employed Mendelian randomization analyses to investigate this causal association.
The univariable Mendelian randomization analysis results indicate that elevated cathepsin H levels increase the overall risk of lung cancer, adenocarcinoma, and lung cancer among smokers.
Conversely, reverse Mendelian randomization analyses suggest that squamous carcinoma may lead to increased cathepsin B levels.
A multivariable analysis using nine cathepsins as covariates reveals that elevated cathepsin H levels lead to an increased overall risk of lung cancer, adenocarcinoma, and lung cancer in smokers.
In conclusion, cathepsin H may serve as a marker for lung cancer, potentially inspiring directions in lung cancer diagnosis and treatment.
A Mendelian randomization analysis identifies a potential causal link between cathepsin H and lung cancer risk.
Li, Jialin,Tang, Mingbo,Gao, Xinliang,Tian, Suyan,Liu, Wei, 2023, Mendelian randomization analyses explore the relationship between cathepsins and lung cancer, Nature
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