Détail du document
Identifiant
doi:10.1007/s00415-023-11642-0...
Auteur
Filippi, Massimo Cecchetti, Giordano Cagnin, Annachiara Marra, Camillo Nobili, Flavio Parnetti, Lucilla Agosta, FedericaLangue
enEditeur
Springer
Catégorie
Medicine & Public Health
Année
2023
Date de référencement
15/03/2023
Mots clés
expert opinion alzheimer italy disease-modifying therapies monoclonal antibodies therapies clinical center adRésumé
No disease-modifying therapies are currently available for Alzheimer’s disease (AD) in Europe.
Current evidence from clinical trials testing anti-beta amyloid (Aβ) monoclonal antibodies (mAbs) in patients with early AD, though, suggests a likely marketing authorization in the next years.
Since the implementation of disease-modifying therapies for AD in the clinical practice will evidently require a huge change of dementia care in all countries, a group of prominent AD clinical experts in Italy met to discuss patients’ selection and management strategies.
The current diagnostic–therapeutic standard of care in Italy was taken as the starting point.
The prescription of new therapies cannot ignore the definition of a biological diagnosis through the assessment of both amyloid- and tau-related biomarkers.
The high risk/benefit ratio of anti-Aβ immunotherapies, moreover, needs a highly specialized diagnostic work-up and a thorough exclusion criteria assessment, which should be provided by a neurology specialist.
The Expert Panel also suggests a reorganization of the Centers for dementia and cognitive decline in Italy into 3 levels of increasing complexity: community center, first- and second-level center.
Tasks and requirements for each level were defined.
Finally, specific characteristics of a center deputed to prescribe anti-Aβ mAbs were discussed.
Filippi, Massimo,Cecchetti, Giordano,Cagnin, Annachiara,Marra, Camillo,Nobili, Flavio,Parnetti, Lucilla,Agosta, Federica, 2023, Redefinition of dementia care in Italy in the era of amyloid-lowering agents for the treatment of Alzheimer’s disease: an expert opinion and practical guideline, Springer
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