Détail du document
Identifiant
doi:10.1007/s10238-023-01113-1...
Auteur
Guo, Haiwei Liu, Ruiqi Wu, Jiajun Li, Shuang Yao, Weiping Xu, Jiajie Zheng, Chuanming Lu, Yanwei Zhang, HaiboLangue
enEditeur
Springer
Catégorie
Medicine & Public Health
Année
2023
Date de référencement
14/06/2023
Mots clés
... papillary thyroid cancer migration proliferation ... papillary ptc thyroid cancer srpx2Résumé
Thyroid cancer is the endocrine tumor with the highest incidence at present.
It originates from the thyroid follicular epithelium or follicular paraepithelial cells.
There is an increasing incidence of thyroid cancer all over the world.
We found that SRPX2 expression level was higher in papillary thyroid tumors than in normal thyroid tissues, and SRPX2 expression was closely related to tumor grade and clinical prognosis.
Previous reports showed that SRPX2 could function by activating PI3K/AKT signaling pathway.
In addition, in vitro experiments showed that SRPX2 promoted the proliferation and migration of papillary thyroid cancer (PTC).
In conclusion, SRPX2 could promote the malignant development of PTC.
This may be a potential treatment target for PTC.
Guo, Haiwei,Liu, Ruiqi,Wu, Jiajun,Li, Shuang,Yao, Weiping,Xu, Jiajie,Zheng, Chuanming,Lu, Yanwei,Zhang, Haibo, 2023, SRPX2 promotes cancer cell proliferation and migration of papillary thyroid cancer, Springer
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