Détail du document
Identifiant
doi:10.1186/s12902-023-01340-3...
Auteur
Malindisa, Evangelista Balandya, Emmanuel Njelekela, Marina Kidenya, Benson R. Francis, Filbert Mmbaga, Blandina T. Dika, Haruna Lyamuya, Eligius Sunguya, Bruno Bartlett, John PrayGod, GeorgeLangue
enEditeur
BioMed Central
Catégorie
Medicine & Public Health
Année
2023
Date de référencement
26/04/2023
Mots clés
mets hiv antiretroviral therapy hiv therapy associated risk plhiv prevalence data antiretroviral mets 0Résumé
Background HIV and antiretroviral drugs, particularly protease inhibitors and nucleoside reverse transcriptase inhibitors, may increase the risk of Metabolic Syndrome (MetS) among people living with HIV (PLHIV).
However, following the introduction of better drugs like dolutegravir, data on the burden of MetS are limited.
This study aimed to assess the prevalence of MetS and associated factors among PLHIV on antiretroviral therapy (ART) in Tanzania.
Methods This was a cross-sectional study among PLHIV aged ≥ 18 years on antiretroviral therapy for ≥ 1 year at Bugando Medical Centre in Mwanza conducted in 2020.
Demographic and healthy-lifestyle-related non-communicable disease risk factors data were collected.
Additionally, data on lipid profile, blood glucose, blood pressure, and waist circumference were collected for analysis of MetS according to the International Diabetes Federation criteria.
Factors associated with MetS were assessed using logistic regression.
A P ≤ 0.05 was considered statistically significant.
Results Data for 223 participants were analyzed.
The mean (SD) age was 44 (± 12) years and 79.8% (178) were females.
A majority 78% (174) were on a tenofovir, lamivudine,and dolutegravir regimen.
About 12.1% (27) were either current or past smokers, 45.3% (101) were past alcohol drinkers, 22.9% (51) were current drinkers, 12.1% (27) reported taking ≥ 5 servings of vegetables and fruits per day and 5.8% (13) were physically inactive.
The prevalence of MetS was 22.9%.
The only factors that were associated with Mets were fat mass index and adequate intake of vegetables and fruits, (adjusted odds ratio (aOR) 2.9, 95% CI 1.0, 7.9, P = 0.04) and (aOR1.2, 95% CI 1.0, 1.3, P = 0.02), respectively).
Conclusion The prevalence of MetS remains high among PLHIV.
Adiposity and adequate fruit and vegetable intake increased the risk.
The introduction of new ART regimens shows no effect on MetS prevalence.
Research is needed to understand how lifestyle changes could reduce MetS in PLHIV.
Malindisa, Evangelista,Balandya, Emmanuel,Njelekela, Marina,Kidenya, Benson R.,Francis, Filbert,Mmbaga, Blandina T.,Dika, Haruna,Lyamuya, Eligius,Sunguya, Bruno,Bartlett, John,PrayGod, George, 2023, Metabolic syndrome among people living with HIV on antiretroviral therapy in Mwanza, Tanzania, BioMed Central
