Détail du document
Identifiant
doi:10.1186/s12981-023-00545-9...
Auteur
Bartoletti, Alice Delvino, Paolo Minetto, Marco Milanesi, Alessandra Bozzalla Cassione, Emanuele Quadrelli, Verdiana Serena Luinetti, Ombretta Monti, Sara Montecucco, CarlomaurizioLangue
enEditeur
BioMed Central
Catégorie
Medicine & Public Health
Année
2023
Date de référencement
26/07/2023
Mots clés
hiv aids iga vasculitis cmv treatment immunodeficiency colitisRésumé
Background Human immunodeficiency virus (HIV) has a protean clinical picture, in rare instances manifesting as systemic autoimmune disorders such as vasculitides.
HIV-induced autoimmune diseases often do not respond well to systemic immunosuppressive therapy.
Opportunistic infections may occur in patients with either acquired immunodeficiency syndrome (AIDS) or heavy immunosuppressive treatment, and can further complicate the clinical presentation.
Case presentation A patient presenting with immunoglobulin A (IgA) vasculitis (IgAV) with treatment-refractory purpuric skin rash and suspect intestinal vasculitis was discovered to have AIDS.
HIV was the trigger of IgAV, and cytomegalovirus (CMV) colitis mimicked intestinal vasculitis.
Antiretroviral treatment improved both CMV colitis and the control of the autoimmune disease.
Conclusions An autoimmune disease relapsing despite adequate immunosuppressive treatment and/or the presence of recurrent severe opportunistic infections may be clues to an underlying HIV infection.
Bartoletti, Alice,Delvino, Paolo,Minetto, Marco,Milanesi, Alessandra,Bozzalla Cassione, Emanuele,Quadrelli, Verdiana Serena,Luinetti, Ombretta,Monti, Sara,Montecucco, Carlomaurizio, 2023, Cytomegalovirus colitis unmasking human immunodeficiency virus infection as a cause of IgA vasculitis, BioMed Central
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