Détail du document
Identifiant
doi:10.1186/s12866-023-03059-6...
Auteur
Shariff, Malini Ramengmawi, ElizabethLangue
enEditeur
BioMed Central
Catégorie
Mycology
Année
2023
Date de référencement
25/10/2023
Mots clés
anaerobic bacteria respiratory infections antimicrobial resistance genera anaerobic infections isolates patients respiratoryRésumé
Background Anaerobes are normal flora of the human body.
However, they can cause serious infections in humans.
Anaerobic bacteria are known to cause respiratory infections like pneumonia and acute exacerbation of chronic lower airway infections.
These are often missed due to the complexity of their isolation and identification.
Hence, this study aimed to study anaerobes causing respiratory tract infections and determine their antibiotic susceptibility.
Materials & methods Clinical specimens such as bronchial aspirates and pleural aspirates collected from patients with respiratory diseases attending Vallabhbhai Patel Chest Institute were processed, the anaerobes isolated were identified, and their susceptibilities to various groups of antimicrobials were studied using standard microbiological methods.
Results Three hundred and fourteen patients were included in the study, 154 males and 160 females.
Of these 314 patients, 148 (47%) yielded anaerobes in their clinical samples.
Seventy patients had more than one type of anaerobic organism.
Hence, 235 isolates were recovered belonging to as many as 17 genera.
The MIC of seven antibiotics on 154 isolates was tested.
The isolates belonged mostly to the genera Bacteroides, Prevotella, Veillonella, and Actinomyces .
Variable resistance was observed to most classes of antibiotics by many genera.
Conclusions Metronidazole is commonly used against anaerobes, but the study showed that the isolates were 20–30% resistant to the antibiotic.
Starting this as an empirical therapy might lead to treatment failure.
Shariff, Malini,Ramengmawi, Elizabeth, 2023, Antimicrobial resistance pattern of anaerobic bacteria causing lower respiratory tract infections, BioMed Central
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