Détail du document
Identifiant
doi:10.1186/s12866-023-03085-4...
Auteur
Shady, Nourhan Hisham Sobhy, Sara Khalid Mostafa, Yaser A. Yahia, Ramadan Glaeser, Stefanie P. Kämpfer, Peter El-Katatny, Mo’men H. Abdelmohsen, Usama RamadanLangue
enEditeur
BioMed Central
Catégorie
Mycology
Année
2023
Date de référencement
22/11/2023
Mots clés
... endophytes metabolomics antimicrobial molecular docking metabolites atccRésumé
Endophytic fungi, particularly from higher plants have proven to be a rich source of antimicrobial secondary metabolites.
The purpose of this study is to examine the antimicrobial potential of three endophytic fungi Aspergillus sp.
SA1, Aspergillus sp.
SA2, and Aspergillus sp.
SA3, cultivated from Nigella sativa seeds against Staphylococcus aureus (ATCC 9144), Escherichia coli (ATCC 25922), Pseudomonas aeruginosa (ATCC 27853), Klebsiella pneumoniae (ATCC 13883), MRSA (ATCC 33591), and human pathogen Candida albicans (ATCC 10231).
Furthermore, the most active cultivated endophytic fungi were molecularly identified via internal transcribed spacer (ITS) sequencing.
HR-ESIMS guided approach has been used successfully in chemical profiling of 26 known bioactive secondary metabolites (1–26), which belongs to different classes of natural compounds such as polyketides, benzenoids, quinones, alcohols, phenols or alkaloids.
Finally, in-silico interactions within active site of fungal Cyp51 and bacterial DNA gyrase revealed possibility of being a hit-target for such metabolites as antimicrobials.
Shady, Nourhan Hisham,Sobhy, Sara Khalid,Mostafa, Yaser A.,Yahia, Ramadan,Glaeser, Stefanie P.,Kämpfer, Peter,El-Katatny, Mo’men H.,Abdelmohsen, Usama Ramadan, 2023, Phytochemical analysis and anti-infective potential of fungal endophytes isolated from Nigella sativa seeds, BioMed Central
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