Détail du document
Identifiant
doi:10.1186/s12866-024-03244-1...
Auteur
Zhang, Yao Wu, Xu Li, Dan Huang, Rong Deng, Xiangyu Li, Mingxing Du, Fukuan Zhao, Yueshui Shen, Jing Chen, Yu Zhang, Pingxiu Hu, Congcui Xiao, Zhangang Wen, QinglianLangue
enEditeur
BioMed Central
Catégorie
Mycology
Année
2024
Date de référencement
27/03/2024
Mots clés
human papillomavirus cervical screening cervicovaginal microbiota metabolomics microbiota results cervicovaginal acidRésumé
Background Cervicovaginal microbiome plays an important role in the persistence of HPV infection and subsequent disease development.
However, cervicovaginal microbiota varied cross populations with different habits and regions.
Identification of population-specific biomarkers from cervicovaginal microbiota and host metabolome axis may support early detection or surveillance of HPV-induced cervical disease at all sites.
Therefore, in the present study, to identify HPV-specific biomarkers, cervicovaginal secretion and serum samples from HPV-infected patients (HPV group, n = 25) and normal controls (normal group, n = 17) in Xichang, China were collected for microbiome (16S rRNA gene sequencing) and metabolome (UHPLC-MS/MS) analysis, respectively.
Results The results showed that key altered metabolites of 9,10-DiHOME, α -linolenic acid, ethylparaben, glycocholic acid, pipecolic acid, and 9,12,13-trihydroxy-10(E),15(Z)-octadecadienoic acid, correlating with Sneathia (Sneathia_amnii), Lactobacillus ( Lactobacillus_iners), Atopobium, Mycoplasma , and Gardnerella , may be potential biomarkers of HPV infection.
Conclusion The results of current study would help to reveal the association of changes in cervicovaginal microbiota and serum metabolome with HPV infections.
Zhang, Yao,Wu, Xu,Li, Dan,Huang, Rong,Deng, Xiangyu,Li, Mingxing,Du, Fukuan,Zhao, Yueshui,Shen, Jing,Chen, Yu,Zhang, Pingxiu,Hu, Congcui,Xiao, Zhangang,Wen, Qinglian, 2024, HPV-associated cervicovaginal microbiome and host metabolome characteristics, BioMed Central
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