Détail du document
Identifiant
doi:10.1186/s12866-024-03327-z...
Auteur
Zhang, Sukai Ma, Chen Zhang, Haiyue Zhao, Congcong Guo, Ruibing Liu, Jiahao Wang, Jing Yuan, Jing Jia, Kai Wu, Airong Chen, Yanjiong Lei, Jin’eLangue
enEditeur
BioMed Central
Catégorie
Mycology
Année
2024
Date de référencement
29/05/2024
Mots clés
... toxin genes toxin gene expression antibiotic resistance resistance xi’an isolates cdi antibiotic strains difficileRésumé
Background Clostridioides difficile is the main pathogen of antimicrobial-associated diarrhoea and health care facility-associated infectious diarrhoea.
This study aimed to investigate the prevalence, toxin genotypes, and antibiotic resistance of C. difficile among hospitalized patients in Xi’an, China.
Results We isolated and cultured 156 strains of C. difficile , representing 12.67% of the 1231 inpatient stool samples collected.
Among the isolates, tcdA + B + strains were predominant, accounting for 78.2% (122/156), followed by 27 tcdA-B + strains (27/156, 17.3%) and 6 binary toxin gene-positive strains.
The positive rates of three regulatory genes, tcdC , tcdR , and tcdE , were 89.1% (139/156), 96.8% (151/156), and 100%, respectively.
All isolates were sensitive to metronidazole, and the resistance rates to clindamycin and cephalosporins were also high.
Six strains were found to be resistant to vancomycin.
Conclusion Currently, the prevalence rate of C. difficile infection (CDI) in Xi’an is 12.67% (156/1231), with the major toxin genotype of the isolates being tcdA + tcdB + cdtA-/B- .
Metronidazole and vancomycin were still effective drugs for the treatment of CDI, but we should pay attention to antibiotic management and epidemiological surveillance of CDI.
Zhang, Sukai,Ma, Chen,Zhang, Haiyue,Zhao, Congcong,Guo, Ruibing,Liu, Jiahao,Wang, Jing,Yuan, Jing,Jia, Kai,Wu, Airong,Chen, Yanjiong,Lei, Jin’e, 2024, Toxin genotypes, antibiotic resistance and their correlations in Clostridioides difficile isolated from hospitals in Xi’an, China, BioMed Central
