Détail du document
Identifiant
doi:10.1186/s12974-022-02446-6...
Auteur
Fu, Jiajia Huang, Yan Bao, Ting Liu, Chengcheng Liu, Xi Chen, XuepingLangue
enEditeur
BioMed Central
Catégorie
Neurology
Année
2022
Date de référencement
08/12/2022
Mots clés
th17 il-17a alzheimer’s disease parkinson’s disease amyotrophic lateral sclerosis targeted therapy th17/il-17a diseasesRésumé
Neurodegenerative diseases are a group of disorders characterized by progressive loss of certain populations of neurons, which eventually lead to dysfunction.
These diseases include Alzheimer’s disease (AD), Parkinson’s disease (PD), and amyotrophic lateral sclerosis (ALS).
Immune pathway dysregulation is one of the common features of neurodegeneration.
Recently, there is growing interest in the specific role of T helper Th 17 cells and Interleukin-17A (IL-17A), the most important cytokine of Th 17 cells, in the pathogenesis of the central nervous system (CNS) of neurodegenerative diseases.
In the present study, we summarized current knowledge about the function of Th17/IL-17A, the physiology of Th17/IL-17A in diseases, and the contribution of Th17/IL-17A in AD, PD, and ALS.
We also update the findings on IL-17A-targeting drugs as potentially immunomodulatory therapeutic agents for neurodegenerative diseases.
Although the specific mechanism of Th17/IL-17A in this group of diseases is still controversial, uncovering the molecular pathways of Th17/IL-17A in neurodegeneration allows the identification of suitable targets to modulate these cellular processes.
Therapeutics targeting IL-17A might represent potentially novel anti-neurodegeneration drugs.
Fu, Jiajia,Huang, Yan,Bao, Ting,Liu, Chengcheng,Liu, Xi,Chen, Xueping, 2022, The role of Th17 cells/IL-17A in AD, PD, ALS and the strategic therapy targeting on IL-17A, BioMed Central
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