Détail du document
Identifiant
doi:10.1186/s13024-021-00479-8...
Auteur
Bono, Silvia Feligioni, Marco Corbo, MassimoLangue
enEditeur
BioMed Central
Catégorie
Neurology
Année
2021
Date de référencement
08/12/2022
Mots clés
amyotrophic lateral sclerosis oxidative stress keap1-nrf2 neuroprotection therapeutic target antioxidant als osRésumé
Background Oxidative stress (OS) is an imbalance between oxidant and antioxidant species and, together with other numerous pathological mechanisms, leads to the degeneration and death of motor neurons (MNs) in amyotrophic lateral sclerosis (ALS).
Main body Two of the main players in the molecular and cellular response to OS are NRF2, the transcription nuclear factor erythroid 2-related factor 2, and its principal negative regulator, KEAP1, Kelch-like ECH (erythroid cell-derived protein with CNC homology)-associated protein 1.
Here we first provide an overview of the structural organization, regulation, and critical role of the KEAP1-NRF2 system in counteracting OS, with a focus on its alteration in ALS.
We then examine several compounds capable of promoting NRF2 activity thereby inducing cytoprotective effects, and which are currently in different stages of clinical development for many pathologies, including neurodegenerative diseases.
Conclusions Although challenges associated with some of these compounds remain, important advances have been made in the development of safer and more effective drugs that could actually represent a breakthrough for fatal degenerative diseases such as ALS.
Bono, Silvia,Feligioni, Marco,Corbo, Massimo, 2021, Impaired antioxidant KEAP1-NRF2 system in amyotrophic lateral sclerosis: NRF2 activation as a potential therapeutic strategy, BioMed Central
SliM-LLM: Salience-Driven Mixed-Precision Quantization for Large Language Models
methods salience efficiency quantization language slim-llm llms
Prediction Models for Suicide Attempts among Adolescents Using Machine Learning Techniques
using data ml prediction 0 suicide adolescents
