Long-Term Mesh Exposure 5 Years Following Minimally Invasive Total Hysterectomy and Sacrocolpopexy

Introduction and Hypothesis The objective was to assess long-term mesh complications following total hysterectomy and sacrocolpopexy.

Methods In this second extension study, women from a multicenter randomized trial were followed for more than 36 months after surgery.

Owing to COVID-19, participants were assessed through either in-person visits or telephone questionnaires.

The primary outcome was the incidence of permanent suture or mesh exposure.

Secondary outcomes included surgical success and late adverse outcomes.

Results Out of the 200 initially enrolled participants, 82 women took part in this second extension study.

Among them, 46 were in the permanent suture group, and 36 in the delayed absorbable group.

The mean follow-up duration was 5.3 years, with the cumulative mesh or suture exposure of 9.9%, involving 18 cases, of which 4 were incident cases.

Surgical success after more than 5 years stood at 95%, with few experiencing bothersome bulge symptoms or requiring retreatment.

No serious adverse events occurred, including mesh erosion into the bladder or bowel.

The most common adverse events were vaginal pain, bleeding, dyspareunia, and stress urinary incontinence, with no significant differences between suture types.

Conclusion The study found that mesh exposure risk gradually increased over time, reaching nearly 10% after more than 5 years post-surgery, regardless of suture type.

However, surgical success remained high, and no delayed serious adverse events were reported.