Détail du document
Identifiant
doi:10.1007/s00345-024-05050-w...
Auteur
Dogha, Mohamed Mahmoud Shaker, Hossam Abdelazeez, Assem Abd-El Latif, Ahmed ElAdawy, Mahmoud S.Langue
enEditeur
Springer
Catégorie
Urology
Année
2024
Date de référencement
05/06/2024
Mots clés
bph unfit tamsulosin double dose score intervention prostate qmax ipss 0 tamsulosin volume dose patients bphRésumé
Aim This study aims to evaluate the effectiveness and safety of administering double-dose tamsulosin (0.8 mg) for treating patients with benign prostatic hyperplasia (BPH) who have not responded to the standard single dose of tamsulosin (0.4 mg) and are deemed unsuitable for transurethral resection (TUR) intervention.
Materials and methods Between November 2022 and July 2023, we prospectively analyzed 111 patients who were experiencing severe BPH symptoms.
These patients received a double dose of tamsulosin for one month.
We collected baseline characteristics such as age, body mass index, and underlying medical conditions.
Various parameters including the International Prostate Symptom Score (IPSS), prostate-specific antigen (PSA) levels, prostate volume, peak urinary flow rate (Qmax), voided volume, and post-void residual volume were evaluated before and after treatment.
Results All 111 patients completed the study.
The mean age, PSA level, and prostate volume were 63.12 ± 4.83 years, 3.42 ± 0.93 ng/ml, and 50.37 ± 19.23 ml, respectively.
Of these patients, 93 showed improvement in Qmax, post-void residual volume, and IPSS score ( p -value = 0.001).
The total IPSS score and total Qmax improved from 24.03 ± 2.49 and 7.72 ± 1.64 ml/sec to 16.41 ± 3.84 and 12.08 ± 2.37 ml/sec, respectively.
Conclusion Double-dose 0.8mg tamsulosin as an alpha-blocker therapy appears to be a viable temporary management option for BPH patients who have not responded to the standard single dose 0.4mg tamsulosin and are not suitable candidates for TUR intervention.
Dogha, Mohamed Mahmoud,Shaker, Hossam,Abdelazeez, Assem,Abd-El Latif, Ahmed,ElAdawy, Mahmoud S., 2024, Tamsulosin 0.8 mg daily dose in management of BPH patients with failed tamsulosin 0.4 mg monotherapy and unfit for surgical intervention, Springer
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