Détail du document
Identifiant
oai:pubmedcentral.nih.gov:1145...
Sujet
ReviewAuteur
Berdyshev, EvgenyLangue
enEditeur
The Korean Academy of Asthma, Allergy and Clinical Immunology; The Korean Academy of Pediatric Allergy and Respiratory Disease
Catégorie
Allergy, Asthma & Immunology Research
Année
2024
Date de référencement
09/10/2024
Mots clés
lipid lipids function barrierRésumé
Lipids are important skin components that provide, together with proteins, barrier function of the skin.
Keratinocyte terminal differentiation launches unique metabolic changes to lipid metabolism that result in the predominance of ceramides within lipids of the stratum corneum (SC)—the very top portion of the skin.
Differentiating keratinocytes form unique ceramides that can be found only in the skin, and generate specialized extracellular structures known as lamellae.
Lamellae establish tight hydrophobic layers between dying keratinocytes to protect the body from water loss and also from penetration of allergens and bacteria.
Genetic and immunological factors may lead to the failure of keratinocyte terminal differentiation and significantly alter the proportion between SC components.
The consequence of such changes is loss or deterioration of skin barrier function that can lead to pathological changes in the skin.
This review summarizes our current understanding of the role of lipids in skin barrier function.
It also draws attention to the utility of testing SC for lipid and protein biomarkers to predict future onset of allergic skin diseases.
Berdyshev, Evgeny, 2024, Skin Lipid Barrier: Structure, Function and Metabolism, The Korean Academy of Asthma, Allergy and Clinical Immunology; The Korean Academy of Pediatric Allergy and Respiratory Disease
Clinical Relevance of Plaque Distribution for Basilar Artery Stenosis
study endovascular imaging wall basilar complications plaque postoperative artery plaques stenosis
