Détail du document
Identifiant
oai:pubmedcentral.nih.gov:9541...
Sujet
Regular Issue ArticlesAuteur
Olson, Joseph W. Nakhmani, Arie Irwin, Zachary T. Edwards, Lloyd J. Gonzalez, Christopher L. Wade, Melissa H. Black, Sarah D. Awad, Mohammad Z. Kuhman, Daniel J. Hurt, Christopher P. Guthrie, Bart L. Walker, Harrison C.Langue
enEditeur
John Wiley & Sons, Inc.
Catégorie
Wiley-Blackwell Online Open
Année
2022
Date de référencement
01/12/2023
Mots clés
parkinson spectral hand beta stn power foot rest pdRésumé
BACKGROUND: Dystonia is an understudied motor feature of Parkinson's disease (PD).
Although considerable efforts have focused on brain oscillations related to the cardinal symptoms of PD, whether dystonia is associated with specific electrophysiological features is unclear.
OBJECTIVE: The objective of this study was to investigate subcortical and cortical field potentials at rest and during contralateral hand and foot movements in patients with PD with and without dystonia.
METHODS: We examined the prevalence and distribution of dystonia in patients with PD undergoing deep brain stimulation surgery.
During surgery, we recorded intracranial electrophysiology from the motor cortex and directional electrodes in the subthalamic nucleus (STN) both at rest and during self‐paced repetitive contralateral hand and foot movements.
Wavelet transforms and mixed models characterized changes in spectral content in patients with and without dystonia.
RESULTS: Dystonia was highly prevalent at enrollment (61%) and occurred most commonly in the foot.
Regardless of dystonia status, cortical recordings display beta (13–30 Hz) desynchronization during movements versus rest, while STN signals show increased power in low frequencies (6.0 ± 3.3 and 4.2 ± 2.9 Hz peak frequencies for hand and foot movements, respectively).
Patients with PD with dystonia during deep brain stimulation surgery displayed greater M1 beta power at rest and STN low‐frequency power during movements versus those without dystonia.
CONCLUSIONS: Spectral power in motor cortex and STN field potentials differs markedly during repetitive limb movements, with cortical beta desynchronization and subcortical low‐frequency synchronization, especially in patients with PD with dystonia.
Greater knowledge on field potential dynamics in human motor circuits can inform dystonia pathophysiology in PD and guide novel approaches to therapy.
© 2022 The Authors.
Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society
Olson, Joseph W.,Nakhmani, Arie,Irwin, Zachary T.,Edwards, Lloyd J.,Gonzalez, Christopher L.,Wade, Melissa H.,Black, Sarah D.,Awad, Mohammad Z.,Kuhman, Daniel J.,Hurt, Christopher P.,Guthrie, Bart L.,Walker, Harrison C., 2022, Cortical and Subthalamic Nucleus Spectral Changes During Limb Movements in Parkinson's Disease Patients with and Without Dystonia, John Wiley & Sons, Inc.
SliM-LLM: Salience-Driven Mixed-Precision Quantization for Large Language Models
methods salience efficiency quantization language slim-llm llms
Prediction Models for Suicide Attempts among Adolescents Using Machine Learning Techniques
using data ml prediction 0 suicide adolescents
