Détail du document
Identifiant
oai:pubmedcentral.nih.gov:8256...
Sujet
ResearchAuteur
Pang, Yong Kek Ismail, Ahmad Izuanuddin Chan, Yoke Fun Cheong, Adelina Chong, Yoong Min Doshi, Paras Lau, Joanne Zhi Han Khor, Jean Wang, Lilian Phei Lian Leong, Chee Loon Musa, Aisya Natasya Ng, Kee Sing Poh, Mau Ern Sam, I-Ching Tan, Jiunn Liang Zim, Mohd Arif Mohd Taurel, Anne-FriedaLangue
enEditeur
BioMed Central
Catégorie
BMC Infectious Diseases
Année
2021
Date de référencement
05/12/2023
Mots clés
acute patients icu/hdu exacerbation influenza 0Résumé
BACKGROUND: Available data on influenza burden across Southeast Asia are largely limited to pediatric populations, with inconsistent findings.
METHODS: We conducted a multicenter, hospital-based active surveillance study of adults in Malaysia with community-acquired pneumonia (CAP), acute exacerbation of chronic obstructive pulmonary disease (AECOPD) and acute exacerbation of asthma (AEBA), who had influenza-like illness ≤10 days before hospitalization.
We estimated the rate of laboratory-confirmed influenza and associated complications over 13 months (July 2018–August 2019) and described the distribution of causative influenza strains.
We evaluated predictors of laboratory-confirmed influenza and severe clinical outcomes using multivariate analysis.
RESULTS: Of 1106 included patients, 114 (10.3%) were influenza-positive; most were influenza A (85.1%), with A/H1N1pdm09 being the predominant circulating strain during the study following a shift from A/H3N2 from January–February 2019 onwards.
In multivariate analyses, an absence of comorbidities (none versus any comorbidity [OR (95%CI), 0.565 (0.329–0.970)], p = 0.038) and of dyspnea (0.544 (0.341–0.868)], p = 0.011) were associated with increased risk of influenza positivity.
Overall, 184/1106 (16.6%) patients were admitted to intensive care or high-dependency units (ICU/HDU) (13.2% were influenza positive) and 26/1106 (2.4%) died (2.6% were influenza positive).
Males were more likely to have a severe outcome (ICU/HDU admission or death).
CONCLUSIONS: Influenza was a significant contributor to hospitalizations associated with CAP, AECOPD and AEBA.
However, it was not associated with ICU/HDU admission in this population.
Study registration, NMRR ID: NMRR-17-889-35,174.
SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s12879-021-06360-9.
Pang, Yong Kek,Ismail, Ahmad Izuanuddin,Chan, Yoke Fun,Cheong, Adelina,Chong, Yoong Min,Doshi, Paras,Lau, Joanne Zhi Han,Khor, Jean,Wang, Lilian Phei Lian,Leong, Chee Loon,Musa, Aisya Natasya,Ng, Kee Sing,Poh, Mau Ern,Sam, I-Ching,Tan, Jiunn Liang,Zim, Mohd Arif Mohd,Taurel, Anne-Frieda, 2021, Influenza in Malaysian adult patients hospitalized with community-acquired pneumonia, acute exacerbation of chronic obstructive pulmonary disease or asthma: a multicenter, active surveillance study, BioMed Central
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