Détail du document
Identifiant
oai:pubmedcentral.nih.gov:9590...
Sujet
ResearchAuteur
Bagherzadeh-Fard, Mahsa Yazdanifar, Mohammad Amin Aghaali, Mohammad Masoumi, MaryamLangue
enEditeur
BioMed Central
Catégorie
BMC Rheumatology
Année
2022
Date de référencement
12/12/2023
Mots clés
ra anti-tpo p-value > 0 001 or = 2 diseases autoimmune controls thyroid common patientsRésumé
BACKGROUND: Rheumatoid arthritis (RA) is one of the most common chronic non-organ-specific autoimmune diseases; meanwhile, autoimmune thyroid disease (AITD) is the most common organ-specific autoimmune disease that can lead to hypo or hyperthyroidism.
Although the etiology of both diseases is complex with a combination of genetic and environmental factors, there are overlaps in genes contributing to the pathogenesis of both diseases.
Numerous studies found a correlation between thyroid abnormality and RA in different populations, yet some didn’t.
This study is aimed to evaluate the prevalence of thyroid dysfunction, AITD, and anti-thyroid peroxidase (anti-TPO) positively in Iranian patients with RA.
METHODS: A total of 250 RA patients and 248 patients with non-inflammatory rheumatologic disease were included in this case–control study.
All participants underwent complete clinical and laboratory assessments.
Participants were also assessed for thyroid function testing, including anti-TPO antibodies.
RESULTS: Thyroid dysfunction was twice as common in RA patients as in controls (OR = 2.16; P-value > 0.001).
Overt hypothyroidism was the most common thyroid dysfunction among RA patients (58 out of 84).
Anti-TPO positivity was also significantly more common in RA compared with controls (OR = 2.65; P-value > 0.001).
The proportion of controls and RA patients with AITD were 9 and 21.5%, respectively.
AITD was found 2.8 times more common in RA group than controls (OR = 2.77; P-value > 0.001).
CONCLUSION: It was demonstrated that RA was an independent factor associated with thyroid dysfunction and AITD.
SUPPLEMENTARY INFORMATION: The online version contains supplementary material available at 10.1186/s41927-022-00293-9.
Bagherzadeh-Fard, Mahsa,Yazdanifar, Mohammad Amin,Aghaali, Mohammad,Masoumi, Maryam, 2022, The prevalence of thyroid dysfunction and autoimmune thyroid disease in patients with rheumatoid arthritis, BioMed Central
Configurable Safety Tuning of Language Models with Synthetic Preference Data
data preference cst dpo configurable language safety
Affective flexibility as a developmental building block of cognitive reappraisal: An fMRI study
cognitive success affective flexibility
