Détail du document
Identifiant

oai:pubmedcentral.nih.gov:1077...

Sujet
Short Report
Auteur
Magalhães, Andreia D Amstutz, Deborah Petermann, Katrin Debove, Ines Sousa, Mário Maradan-Gachet, Marie E Lachenmayer, Martin Lenard Waskönig, Julia Murcia-Carretero, Sandra Diamantaras, Andreas Antonios Tinkhauser, Gerd Nowacki, Andreas Pollo, Claudio Rodriguez-Blazquez, Carmen Martinez-Martin, Pablo Krack, Paul
Langue
en
Editeur

BMJ Publishing Group

Catégorie

BMJ Neurology Open

Année

2024

Date de référencement

11/06/2024

Mots clés
ci pd 95% p<0 001 acute neuropsychiatric stn-dbs effects conditions
Métrique

Résumé

BACKGROUND: Subthalamic nucleus deep brain stimulation (STN-DBS) is a well-established treatment for motor complications in Parkinson’s disease (PD).

However, its effects on neuropsychiatric symptoms remain disputed.

The aim of this study was to evaluate the effects of STN-DBS on neuropsychiatric symptoms in PD.

METHODS: We retrospectively assessed 26 patients with PD who underwent a preoperative levodopa challenge and postoperative levodopa and stimulation challenges 1 year after STN-DBS.

Based on the Neuropsychiatric Fluctuations Scale, Neuropsychiatric State Scores and Neuropsychiatric Fluctuation Indices (NFIs) were calculated.

Mixed-effects models with random effects for intercept were used to examine the association of Neuropsychiatric State Score and NFI with the different assessment conditions.

RESULTS: In acute challenge conditions, there was an estimated increase of 15.9 points in the Neuropsychiatric State Score in stimulation ON conditions (95% CI 11.4 to 20.6, p<0.001) and 7.6 points in medication ON conditions (95% CI 3.3 to 11.9, p<0.001).

Neuropsychiatric fluctuations induced by levodopa, quantified with NFI, decreased by 35.54% (95% CI 49.3 to 21.8, p<0.001) 1 year after STN-DBS.

CONCLUSIONS: Bilateral STN-DBS at therapeutic parameters has acute psychotropic effects similar to levodopa and can modulate and decrease levodopa-induced neuropsychiatric fluctuations.

Magalhães, Andreia D,Amstutz, Deborah,Petermann, Katrin,Debove, Ines,Sousa, Mário,Maradan-Gachet, Marie E,Lachenmayer, Martin Lenard,Waskönig, Julia,Murcia-Carretero, Sandra,Diamantaras, Andreas Antonios,Tinkhauser, Gerd,Nowacki, Andreas,Pollo, Claudio,Rodriguez-Blazquez, Carmen,Martinez-Martin, Pablo,Krack, Paul, 2024, Subthalamic stimulation has acute psychotropic effects and improves neuropsychiatric fluctuations in Parkinson’s disease, BMJ Publishing Group

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