Détail du document
Identifiant
oai:pubmedcentral.nih.gov:1033...
Sujet
Intensive CareAuteur
Chu, Raymond Bak Hei Zhao, Shi Zhang, Jack Zhenhe Chan, King Chung Kenny Ng, Pauline Yeung Chan, Carol Fong, Ka Man Au, Shek Yin Yeung, Alwin Wai Tak Chan, Jacky Ka Hing Tsang, Hin Hung Law, Kin Ip Chow, Fu Loi Lam, Koon Ngai Chan, Kai Man Dharmangadan, Manimala Wong, Wai Tat Joynt, Gavin Matthew Wang, Maggie Haitian Ling, LowellLangue
enEditeur
BMJ Publishing Group
Catégorie
BMJ Open
Année
2023
Date de référencement
14/12/2023
Mots clés
iv adjusted risk care admitted 95% ci mortality influenza january 0Résumé
OBJECTIVES: Direct comparisons between COVID-19 and influenza A in the critical care setting are limited.
The objective of this study was to compare their outcomes and identify risk factors for hospital mortality.
DESIGN AND SETTING: This was a territory-wide, retrospective study on all adult (≥18 years old) patients admitted to public hospital intensive care units in Hong Kong.
We compared COVID-19 patients admitted between 27 January 2020 and 26 January 2021 with a propensity-matched historical cohort of influenza A patients admitted between 27 January 2015 and 26 January 2020.
We reported outcomes of hospital mortality and time to death or discharge.
Multivariate analysis using Poisson regression and relative risk (RR) was used to identify risk factors for hospital mortality.
RESULTS: After propensity matching, 373 COVID-19 and 373 influenza A patients were evenly matched for baseline characteristics.
COVID-19 patients had higher unadjusted hospital mortality than influenza A patients (17.5% vs 7.5%, p<0.001).
The Acute Physiology and Chronic Health Evaluation IV (APACHE IV) adjusted standardised mortality ratio was also higher for COVID-19 than influenza A patients ((0.79 (95% CI 0.61 to 1.00) vs 0.42 (95% CI 0.28 to 0.60)), p<0.001).
Adjusting for age, P(a)O(2)/F(i)O(2), Charlson Comorbidity Index and APACHE IV, COVID-19 (adjusted RR 2.26 (95% CI 1.52 to 3.36)) and early bacterial-viral coinfection (adjusted RR 1.66 (95% CI 1.17 to 2.37)) were directly associated with hospital mortality.
CONCLUSIONS: Critically ill patients with COVID-19 had substantially higher hospital mortality when compared with propensity-matched patients with influenza A.
Chu, Raymond Bak Hei,Zhao, Shi,Zhang, Jack Zhenhe,Chan, King Chung Kenny,Ng, Pauline Yeung,Chan, Carol,Fong, Ka Man,Au, Shek Yin,Yeung, Alwin Wai Tak,Chan, Jacky Ka Hing,Tsang, Hin Hung,Law, Kin Ip,Chow, Fu Loi,Lam, Koon Ngai,Chan, Kai Man,Dharmangadan, Manimala,Wong, Wai Tat,Joynt, Gavin Matthew,Wang, Maggie Haitian,Ling, Lowell, 2023, Comparison of COVID-19 with influenza A in the ICU: a territory-wide, retrospective, propensity matched cohort on mortality and length of stay, BMJ Publishing Group
MELAS: Phenotype Classification into Classic-versus-Atypical Presentations
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