Détail du document
Identifiant

oai:HAL:pasteur-03408583v1

Sujet
RNAP II cap-snatching influenza polymerase nuclear cap-binding complex promoter-proximal pausing transcription [SDV.BBM.BM]Life Sciences [q-bio]/... [SDV.MP.VIR]Life Sciences [q-bio]/...
Auteur
Krischuns, Tim Lukarska, Maria Naffakh, Nadia Cusack, Stephen
Langue
en
Editeur

HAL CCSD;Annual Reviews

Catégorie

CNRS - Centre national de la recherche scientifique

Année

2021

Date de référencement

29/09/2023

Mots clés
cap-snatching influenza ii flupol rna polymerase rnap transcription
Métrique

Résumé

International audience; Influenza virus RNA-dependent RNA polymerase (FluPol) transcribes the viral RNA genome in the infected cell nucleus.

In the 1970s, researchers showed that viral transcription depends on host RNA polymerase II (RNAP II) activity and subsequently that FluPol snatches capped oligomers from nascent RNAP II transcripts to prime its own transcription.

Exactly how this occurs remains elusive.

Here, we review recent advances in the mechanistic understanding of FluPol transcription and early events in RNAP II transcription that are relevant to cap-snatching.

We describe the known direct interactions between FluPol and the RNAP II C-terminal domain and summarize the transcription-related host factors that have been found to interact with FluPol.

We also discuss open questions regarding how FluPol may be targeted to actively transcribing RNAP II and the exact context and timing of cap-snatching, which is presumed to occur after cap completion but before the cap is sequestered by the nuclear cap-binding complex.

Krischuns, Tim,Lukarska, Maria,Naffakh, Nadia,Cusack, Stephen, 2021, Influenza Virus RNA-Dependent RNA Polymerase and the Host Transcriptional Apparatus, HAL CCSD;Annual Reviews

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