Détail du document
Identifiant
oai:HAL:pasteur-04095417v1
Sujet
[SDV.SPEE]Life Sciences [q-bio]/Sa...Auteur
Tsang, Tim, K Wang, Can Fang, Vicky, J Perera, Ranawaka, a P M So, Hau Chi Ip, Dennis, K M Peiris, J, S Malik Leung, Gabriel, M Cauchemez, Simon Cowling, Benjamin, JLangue
enEditeur
HAL CCSD;MDPI
Catégorie
CNRS - Centre national de la recherche scientifique
Année
2022
Date de référencement
07/10/2023
Mots clés
influenza vaccinated indirect protection infectionRésumé
International audience; Influenza vaccination is an important intervention to prevent influenza virus infection.
Our previous analysis suggested that indirect protection is limited in an influenza B epidemic in Hong Kong.
We further analyzed six influenza A epidemics to determine such potential.
We applied a statistical model to estimate household transmission dynamics in the 3 influenza A(H3N2) and 3 pandemic influenza A(H1N1) epidemics.
Then, we estimated the reduction in infection risk among unvaccinated household members when all children in households are vaccinated, with different assumptions on vaccine efficacy (VE).
In the optimal scenario that VE was 70%, the reduction to the total probability of infection was only marginal, with relative probabilities ranged from 0.91–0.94 when all children in households were vaccinated because community was by far the main source of infection during the six epidemics in our study.
The proportion of cases attributed to household transmission was 10% (95% CrI: 7%, 13%).
Individual influenza vaccination is important even when other household members are vaccinated, given the degree of indirect protection is small.
Tsang, Tim, K,Wang, Can,Fang, Vicky, J,Perera, Ranawaka, a P M,So, Hau Chi,Ip, Dennis, K M,Peiris, J, S Malik,Leung, Gabriel, M,Cauchemez, Simon,Cowling, Benjamin, J, 2022, Indirect Protection from Vaccinating Children against Influenza A Virus Infection in Households, HAL CCSD;MDPI
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