Détail du document
Identifiant
oai:pubmedcentral.nih.gov:1087...
Sujet
Original ResearchAuteur
Zeng, Yinhui Li, Jinyuan Wen, Yueqiang Xiao, Haiqing Yang, Chao Zeng, Qingxiang Liu, WenlongLangue
enEditeur
Dove
Catégorie
Journal of Asthma and Allergy
Année
2024
Date de référencement
16/08/2024
Mots clés
rhinitis inhibitory allergic ar eosinophilsRésumé
PURPOSE: Eosinophils have pivotal roles in the development of allergic rhinitis (AR) through the release of cytotoxic substances.
Apolipoprotein A-I (Apo-AI) exhibits a strong inhibitory effect on eosinophil infiltration in allergic diseases.
Nevertheless, the precise impact of Apolipoprotein A-I on eosinophils remains uncertain.
METHODS: Our study recruited a total of 15 AR children and 15 controls.
The correlation between Apo-AI expression and the counts of blood eosinophils was examined.
Flow cytometry was employed to assess the role of Apo-AI in eosinophil apoptosis and adhesion.
The Transwell system was performed to conduct the migration assay.
An animal model using AR mice was established to test the effect of Apo-AI on eosinophils.
RESULTS: Serum Apo-AI were negatively related to eosinophils counts and eosinophil chemotactic protein levels in AR.
Apo-AI exerts a pro-apoptotic effect while also impeding the processes of adhesion, migration, and activation of eosinophils.
The apoptosis triggered by Apo-AI was facilitated through the phosphoinositide 3-kinase (PI3K) pathway.
The chemotaxis and activation of eosinophils, which are influenced by Apolipoprotein A-I, are regulated through the PI3K and MAPK signaling pathways.
Apo-AI treated mice presented with decreased blood and nasal eosinophilic inflammation as well as down-regulated eosinophil related cytokines.
CONCLUSION: Our findings provide confirmation that Apo-AI exhibits inhibitory effects on the function of eosinophils in allergic rhinitis.
This suggests that Apo-AI holds potential as a therapeutic target for future treatment strategies.
Zeng, Yinhui,Li, Jinyuan,Wen, Yueqiang,Xiao, Haiqing,Yang, Chao,Zeng, Qingxiang,Liu, Wenlong, 2024, Inhibitory Effect of Apolipoprotein A-I on Eosinophils in Allergic Rhinitis in vitro and in vivo, Dove
Configurable Safety Tuning of Language Models with Synthetic Preference Data
data preference cst dpo configurable language safety
Affective flexibility as a developmental building block of cognitive reappraisal: An fMRI study
cognitive success affective flexibility
