Détail du document
Identifiant
oai:pubmedcentral.nih.gov:1046...
Sujet
Original ArticleAuteur
Zhang, Yuxing Zhao, Xin Guo, Chun Zhang, Ying Zeng, Fukang Yin, Qian Li, Zhong Shao, Le Zhou, Desheng Liu, LijuanLangue
enEditeur
Springer Nature Singapore
Catégorie
Neuroscience Bulletin
Année
2023
Date de référencement
04/09/2024
Mots clés
protein stroke ischemic pathway circadianRésumé
Ischemic stroke is a major public health problem worldwide.
Although the circadian clock is involved in the process of ischemic stroke, the exact mechanism of the circadian clock in regulating angiogenesis after cerebral infarction remains unclear.
In the present study, we determined that environmental circadian disruption (ECD) increased the stroke severity and impaired angiogenesis in the rat middle cerebral artery occlusion model, by measuring the infarct volume, neurological tests, and angiogenesis-related protein.
We further report that Bmal1 plays an irreplaceable role in angiogenesis.
Overexpression of Bmal1 promoted tube-forming, migration, and wound healing, and upregulated the vascular endothelial growth factor (VEGF) and Notch pathway protein levels.
This promoting effect was reversed by the Notch pathway inhibitor DAPT, according to the results of angiogenesis capacity and VEGF pathway protein level.
In conclusion, our study reveals the intervention of ECD in angiogenesis in ischemic stroke and further identifies the exact mechanism by which Bmal1 regulates angiogenesis through the VEGF-Notch1 pathway.
Zhang, Yuxing,Zhao, Xin,Guo, Chun,Zhang, Ying,Zeng, Fukang,Yin, Qian,Li, Zhong,Shao, Le,Zhou, Desheng,Liu, Lijuan, 2023, The Circadian System Is Essential for the Crosstalk of VEGF-Notch-mediated Endothelial Angiogenesis in Ischemic Stroke, Springer Nature Singapore
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