Détail du document
Identifiant
oai:HAL:hal-03120461v1
Sujet
Cognition Parkinson's disease Prodromal phase Trajectories [SDV.SPEE]Life Sciences [q-bio]/Sa...Auteur
Foubert-Samier, Alexandra Helmer, Catherine Le Goff, Mélanie Guillet, Florian Proust-Lima, Cecile Jacqmin-Gadda, Helene Dartigues, Jean-François Amieva, Helene Tison, F.Langue
enEditeur
HAL CCSD;Elsevier
Catégorie
sciences : sciences du vivant
Année
2020
Date de référencement
07/12/2023
Mots clés
daily phase depressive global cohort follow-up symptoms parkinson diseaseRésumé
International audience; IntroductionProdromal non-motor symptoms precede, often by decades, motor signs and diagnosis of Parkinson's disease.
It is however still uncertain if cognitive changes belong to the spectrum of non-motor prodromal Parkinson's disease.
Thanks to the very long-term follow-up of the PAQUID population-based cohort, we assessed trajectories of cognitive complaints and functioning over a 13-year period before the diagnosis of late onset Parkinson's disease.MethodsThis study relies on a matched nested case-control sample selected from the cohort.
Of the 3777 initial subjects of the cohort, 43 developed incident Parkinson's disease over the follow-up.
The mean age at diagnosis was 78.0 (standard deviation = 5.8) years and 46.5% were men.
These cases were matched to 86 elderly control subjects.
Scores of different cognitive domains, daily function, and depressive symptoms were described throughout the follow-up using mixed-effects models.ResultsNo significant global cognitive decline preceded the diagnosis of late onset Parkinson's disease.
However, psychomotor speed appeared significantly slower 2 years before the diagnosis and depressive symptoms 12 years before.
Global score of instrumental activities of daily living became altered 2–3 years preceding the diagnosis of late onset Parkinson's disease, including the use of public transportation that was altered ten years before the diagnosis.ConclusionIn late onset Parkinson's disease, while global cognitive functions seem preserved, psychomotor speed starts to decline 2 years before the diagnosis and activities of daily living are also impacted.
Depressive symptoms appear very early in the prediagnosic phase.
Foubert-Samier, Alexandra,Helmer, Catherine,Le Goff, Mélanie,Guillet, Florian,Proust-Lima, Cecile,Jacqmin-Gadda, Helene,Dartigues, Jean-François,Amieva, Helene,Tison, F., 2020, Cognitive and functional changes in prediagnostic phase of Parkinson disease: A population-based study;: Parkinsonism Relat Disord, HAL CCSD;Elsevier
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