Détail du document
Identifiant
oai:pubmedcentral.nih.gov:1020...
Sujet
Full Length ArticleAuteur
Aquilante, Bruna Pultrini Castro, Ana Paula Beltran Moschione Yonamine, Glauce Hiromi de Barros Dorna, Mayra Barp, Mariana Fernandes Martins, Tatiana Paskin da Rosa Pastorino, Antonio CarlosLangue
enEditeur
World Allergy Organization
Catégorie
The World Allergy Organization Journal
Année
2023
Date de référencement
16/08/2024
Mots clés
challenge tests patients ige-mediated anaphylaxis oral food ofc milk cmRésumé
BACKGROUND: Oral food challenge (OFC) is useful for diagnosing food allergies and assessing tolerance, but severe reactions may occur during the procedure.
OBJECTIVE: To characterize the frequency and severity of reactions during cow's milk (CM) OFCs.
METHODS: A cross-sectional study was conducted to analyze the outcome of cow's milk oral food challenges (CMOFCs) performed to confirm IgE-mediated CM allergy or to assess food tolerance.
CM was given first as baked milk (BM), followed by whole CM if there was no prior reaction to BM.
An OFC was considered positive if IgE-mediated symptoms developed up to 2 h after ingestion.
Symptoms were described and variables including age at OFC, prior anaphylaxis, other atopic diseases, and skin test results were compared according to the OFC outcomes.
RESULTS: A total of 266 CMOFCs were performed, including 159 patients with a median age of 6.3 years old.
One hundred thirty-six tests were positive and 62 resulted in anaphylaxis.
Thirty-nine anaphylactic reactions were observed up to 30 min after the first dose.
Severe anaphylaxis (cardiovascular and/or neurological involvement) was reported in 5 tests.
A second dose of epinephrine was required in 3 tests, and 1 presented a biphasic response.
Younger patients had a higher risk of anaphylaxis during baked milk oral food challenge (BMOFC) (p = 0.009).
The frequency of anaphylaxis was higher in patients submitted to BM (p = 0.009).
CONCLUSIONS: Anaphylaxis is a known complication of CMOFCs even when there is no prior anaphylaxis or when conducted with baked products.
This study reinforces the importance of conducting OFC in appropriate settings with a well-trained team.
Aquilante, Bruna Pultrini,Castro, Ana Paula Beltran Moschione,Yonamine, Glauce Hiromi,de Barros Dorna, Mayra,Barp, Mariana Fernandes,Martins, Tatiana Paskin da Rosa,Pastorino, Antonio Carlos, 2023, IgE-mediated cow’s milk allergy in Brazilian children: Outcomes of oral food challenge, World Allergy Organization
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