Every day we put forward for you the scientific studies of the moment
ExploreAlzheimer's disease is a degenerative brain disease. Being the primary cause of Dementia in adults and progressively destroys brain memory. Though Alzheimer's disease does not have a cure currently,...
disease computer brain alzheimer Read morePurpose Predicting the progression of MCI to Alzheimer's disease is an important step in reducing the progression of the disease. Therefore, many methods have been introduced for this task based on ...
based computer science roi method results disease alzheimer rois Read moreInternational audience; Background: The association between omega-3 (ω-3) PUFAs and cognition, brain imaging and biomarkers is still not fully established.Objectives: The aim was to anal...
initiative neuroimaging adjusted tau volume associations omega-3 associated low alzheimer ω-3 aβ lower biomarkers imaging accumulation decline 0 brain disease index cognitive cognition Read moreDisinhibition during early stages of Alzheimer's disease is postulated to cause network dysfunction and hyperexcitability leading to cognitive deficits. However, the underlying molecular mechanism rem...
chloride treatment decline alzheimer kcc2 cognitive Read moreBACKGROUND: Based on its objective characteristics, laboratory markers have always been the research direction of clinical diagnosis and assessment of mental disorders including Alzheimer's disease. M...
levels lps cell-free pha pbmcs secretion stimulated dna alzheimer disease Read moreINTRODUCTION: Previous studies have applied normative modeling on a single neuroimaging modality to investigate Alzheimer Disease (AD) heterogeneity. We employed a deep learning-based multimodal nor...
ad individual-level modeling alzheimer abnormality normative disease atn Read moreOBJECTIVE: To study the clinical effect of nano drug particles in the diagnosis and treatment of Alzheimer's disease in the elderly, we promote the research on the treatment of Alzheimer's disease and...
level elderly diagnosis research clinical alzheimer disease treatment control Read moreSporadic Alzheimer’s disease (AD) is a complex neurological disorder characterized by many risk loci with potential associations with different traits and diseases. AD, characterized by a progressive ...
alzheimer gene expression genetic correlation neural network alzheimer’s disease models ad network neural traits Read moreBackground Based on its objective characteristics, laboratory markers have always been the research direction of clinical diagnosis and assessment of mental disorders including Alzheimer's disease. Me...
alzheimer's disease mitogen peripheral blood mononuclear cell pha lps cell-free levels secretion stimulated pbmcs alzheimer disease mitochondrial dna Read moreBackground Dementia is one of the major causes of disability and dependency among older people worldwide. The formation of an aging population in Iran can be associated with societal problems, includi...
alzheimer dementia prevalence iran systematic review meta-analysis review studies systematic 0 estimated dementia prevalence ci 95% iran Read moreProlonged exposure to glucocorticoids, the main stress hormones, damages the brain and is a risk factor for depression and Alzheimer's disease. Two major drivers of glucocorticoid-related neurotoxicit...
mitochondria pore permeability disease transition alzheimer tau Read moreAge-related neurodegenerative diseases (NDDs) are associated with the aggregation and propagation of specific pathogenic protein species (e.g., Aβ, α-synuclein). However, whether disruption of synapti...
alzheimer homeostasis synaptic error-prone protein Read moreDisinhibition during early stages of Alzheimer's disease is postulated to cause network dysfunction and hyperexcitability leading to cognitive deficits. However, the underlying molecular mechanism rem...
chloride treatment decline alzheimer kcc2 cognitive Read moreReinforcement learning (RL) has recently shown promise in predicting Alzheimer's disease (AD) progression due to its unique ability to model domain knowledge. However, it is not clear which RL algor...
ad alzheimer progression disease model Read moreAlzheimer's Disease (AD) is primarily an irreversible neurodegenerative disorder affecting millions of individuals today. The prognosis of the disease solely depends on treating symptoms as they ari...
structural disease alzheimer Read moreInternational audience; Amyloid PET imaging has been crucial for detecting the accumulation of amyloid beta (Aβ) deposits in the brain and to study Alzheimer's disease (AD). We performed...
amyloidosis p = 1 disease alzheimer genome-wide study 32 imaging apoe amyloid ɛ4 se = 0 maf = 0 β = 0 Read moreInternational audience; The link between Alzheimer's disease (AD) and network hypersynchrony-manifesting as epileptic activities-received considerable attention in the past decade. Howev...
alzheimer model noradrenergic transmission cycle tg2576 disease Read moreBACKGROUND: Alzheimer's disease (AD) has become a common illness affecting the elderly, adding to society's social and financial burden. We used two‐sample Mendelian randomization (MR) in this study t...
study p = 95%ci status alzheimer ad analysis Read moreProlonged exposure to glucocorticoids, the main stress hormones, damages the brain and is a risk factor for depression and Alzheimer's disease. Two major drivers of glucocorticoid-related neurotoxicit...
mitochondria pore permeability disease transition alzheimer tau Read moreÉcole thématique
alzheimer Read moreBackground Based on its objective characteristics, laboratory markers have always been the research direction of clinical diagnosis and assessment of mental disorders including Alzheimer's disease. Me...
alzheimer's disease mitogen peripheral blood mononuclear cell pha lps cell-free levels secretion stimulated pbmcs alzheimer disease mitochondrial dna Read moreHere, using cryo-EM, authors reveal that amyloid-β and tau are identical in Alzheimer disease and Down syndrome. This has implications for assessing whether adults with Down syndrome could be included...
filaments amyloid-β disease alzheimer syndrome ad tau ds Read moreInternational audience; Developed as a regulator of copper homeostasis in the brain of patients affected by Alzheimer's disease (AD), TDMQ20 is a specific copper(II) chelator able to res...
alzheimer chelator disease tdmq20 copper Read moreAlzheimer's disease (AD) is associated with brain alterations, resulting in an impairment of cognitive functions. In recent years, we have been able to establish a link between the dysf...
disease remodelage cela associated remodelling presence induced zone qu animals animaux présence hippocampe jours ee mémoire mice tg2576 souris interneurones memory cognitive pnns ad interneurons cognitives avons effects effets aux pv alzheimer ca1 pnn Read moreNeuroinflammation plays an important role in the pathophysiology of Alzheimer's disease. The cannabinoid type 2 receptor (CB2R) is an emerging target for neuroinflammation and therapeutics of Alzheime...
immunofluorescence mouse model imaging 17-month-old autoradiography specific 24 months expression 17 age mice arcaß disease ntl alzheimer neuroinflammation cb2r Read moreBackground Amyotrophic lateral sclerosis (ALS) is phenotypically heterogeneous in motor manifestations, and the extent of upper vs. lower motor neuron involvement is a widespread descriptor. This stud...
amyotrophic lateral sclerosis frontotemporal degeneration cognitive impairment: upper motor ... lower motor neuron neuron scores ecas-total cognition motor phenotypes classical Read moreAmyotrophic lateral sclerosis (ALS) is associated with considerable clinical heterogeneity spanning from diverse disability profiles, differences in UMN/LMN involvement, divergent progression rates, t...
amyotrophic lateral sclerosis neuroimaging biomarkers motor neuron disease diffusion imaging clinical trials patients profiles subtypes clinical based disease Read moreAmyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease affecting upper and lower motor neurons (MNs). Since the identification of the first ALS mutation in 1993, more than 40 genes h...
amyotrophic lateral sclerosis autophagy mutations animal models protein involved als autophagy Read moreBackground Motor neuron diseases (MND), with amyotrophic lateral sclerosis constituting most cases, are rare conditions of unknown etiology. There have been reports of an increase in incidence during ...
motor neuron disease amyotrophic lateral sclerosis incidence epidemiology age data rate mnd sweden incidence Read moreALCAR (Acetyl-L-carnitine) is a donor of acetyl groups and increases the intracellular levels of carnitine, the primary transporter of fatty acids across the mitochondrial membranes. In vivo studies s...
observational study treatment amyotrophic lateral sclerosis neurological disease case–control efficacy nor baseline compared treated subjects 0 Read moreMutations in FUS, an RNA-binding protein involved in multiple steps of RNA metabolism, are associated with the most severe forms of amyotrophic lateral sclerosis (ALS). Accumulation of cytoplasmic FUS...
amyotrophic lateral sclerosis fronto-temporal dementia mouse models rna-binding proteins fus autoregulation therapy wild-type mutant expression protein fus Read moreThe deposition of aggregated proteins is a common neuropathological denominator for neurodegenerative disorders. Experimental evidence suggests that disease propagation involves prion-like mechanisms ...
amyotrophic lateral sclerosis als superoxide dismutase 1 sod1 protein aggregation prion-like peripheral administration aggregate stability cns als-like inoculations mice cord sod1 spinal hsod1 Read moreBackground Uric acid (UA) has emerged as a factor that can modify cognitive function both in the general population and in people with neurodegenerative disorders. Since very few data are available co...
amyotrophic lateral sclerosis cognition frontotemporal dementia uric acid phenotype als-int cognitive levels impairment als-ftd als ua Read moreAim The study aims to increase understanding of edaravone’s efficacy and safety as an amyotrophic lateral sclerosis (ALS) treatment and provide significant insights regarding this field’s future resea...
edaravone als amyotrophic lateral sclerosis meta-analysis 95% safety efficacy edaravone Read moreAmyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by the degeneration of motor neurons, and there is currently a lack of reliable diagnostic biomarkers. This meta-...
amyotrophic lateral sclerosis chit1 chi3l1 chi3l2 biomarker cerebrospinal fluid blood meta-analysis systematic increase elevated chit1 chitinases smd – 95% ci 001 < 0 compared diagnostic patients 0 Read moreBackground Loss of motor neurons in amyotrophic lateral sclerosis (ALS) leads to progressive paralysis and death. Dysregulation of thousands of RNA molecules with roles in multiple cellular pathways h...
amyotrophic lateral sclerosis -repeat e... pre-clinical models transcriptome genome-wide mechanisms of neuropro... srsf1-dependent rna nuclear export... disease-modifying gene expression ... voltage-gated potassium ion channe... genome-wide export motor pathological human patient-derived therapeutic neuroprotective nuclear transcripts rna neurons Read moreBackground The ALS Functional Rating Scale in its revised version (ALSFRS-R) is a disease-specific severity score that reflects motor impairment and functional deterioration in people with amyotrophic...
amyotrophic lateral sclerosis alsfrs-r patient reported outcomes digital medicine annotated functional options clinical als alsfrs-r-se version adapted Read moreBackground Compared with typical bulbar onset amyotrophic lateral sclerosis (ALS), isolated bulbar palsy (IBP), an often under-understood variant of ALS, is characterized by symptoms confined to bulba...
bulbar palsy amyotrophic lateral sclerosis survival motor neuron prognosis survival 20 months disease onset patients ibp Read moreTDP-43 proteinopathy is a salient neuropathologic feature in a subset of frontotemporal lobar degeneration (FTLD-TDP), in amyotrophic lateral sclerosis (ALS-TDP), and in limbic-predominant age-related...
tdp-43 limbic predominant age-related tdp... frontotemporal lobar degeneration amyotrophic lateral sclerosis hippocampal sclerosis of aging dementia alzheimer’s disease national alzheimer’s coordinating ... alzheimer’s ftld-tdp atrophy available neuropathologic odds pathology tdp-43 data als/ftld-tdp late-nc participants Read moreBackground Neuronal intranuclear inclusion disease (NIID) is a rare neurodegenerative disease. Pathologically, it is characterized by eosinophilic hyaline intranuclear inclusions in the cells of the v...
neuronal intranuclear inclusion di... amyotrophic lateral sclerosis magnetic resonance imaging autopsy paravermal lesion case report disease autopsy lesions motor als niid coexistence intranuclear Read moreBackground Home-monitoring of spirometry has the potential to improve care for patients with a motor neuron disease (MND) by enabling early detection of respiratory dysfunction and reducing travel bur...
motor neuron disease amyotrophic lateral sclerosis respiratory function vital capacity remote monitoring validity test tests supervised patients vc unsupervised home-monitoring mnd Read moreAmyotrophic lateral sclerosis (ALS) is the most common motor neuron (MN) disease, with no present cure. The progressive loss of MNs is the hallmark of ALS. We have previously shown the therapeutic eff...
amyotrophic lateral sclerosis als pten bpv akt motor neuron survival = 0 loss mn treatment significantly pic bpv als msod1^g93a Read moreAmyotrophic lateral sclerosis (ALS) is a progressive and fatal neuromuscular disease that results in the loss of motor neurons and severe skeletal muscle atrophy. The etiology of ALS is linked to skel...
amyotrophic lateral sclerosis mitochondria skeletal muscle dysfunction mitochondrial transplantation mitochondrial therapeutic cells Read moreFrontotemporal lobar degeneration (FTLD) is a clinically, genetically, and neuropathologically heterogeneous group of neurodegenerative syndromes, leading to progressive cognitive dysfunction and fron...
amyotrophic lateral sclerosis autophagy c9orf72 frontotemporal lobar degeneration mitochondrial function ubiquitin–proteasome system respiration compared non-carriers carriers c9-hre patient–derived function fibroblasts Read moreAmyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by the progressive degeneration of both upper and lower motor neurons. A defining histopathological feature in ap...
amyotrophic lateral sclerosis als motor neuron disease non-motor symptoms patients clinical neurons non-motor symptoms als Read moreBackground Amyotrophic Lateral Sclerosis (ALS) is a neurodegenerative disease whose spreading and progression mechanisms are still unclear. The ability to predict ALS prognosis would improve the patie...
amyotrophic lateral sclerosis progression trajectories process mining process discovery patient stratification prognosis patients’ onset data als–bs patients terms process progression als pro-act disease impairment trajectories Read moreAmyotrophic lateral sclerosis (ALS) is a neurodegenerative fatal disorder in which motor neurons within the brain and spinal cord degenerate. A single infusion of mesenchymal stem cells (MSCs) delays ...
amyotrophic lateral sclerosis mesenchymal stem cells intravenous... multiple doses quality of life deterioration function single als compared motor Read moreThe most prominent genetic cause of both amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration (FTLD) is a repeat expansion in the gene C9orf72 . Importantly, the transcriptomic co...
c9orf72 amyotrophic lateral sclerosis frontotemporal lobar degeneration transcriptomics cryptic exons transcriptomic cerebellum repeat expansion Read moreThere is considerable variability in disease progression for patients with amyotrophic lateral sclerosis (ALS) including the age of disease onset, site of disease onset, and survival time. There is gr...
genetic marker structural variant amyotrophic lateral sclerosis clinical trials participant selection enrichment tool responder sub-population clinical markers trials als Read moreObjective Half of ALS patients are cognitively and/or behaviourally impaired. As cognition/behaviour and cerebral glucose metabolism can be correlated by means of ^18F-Fluorodeoxyglucose positron emis...
amyotrophic lateral sclerosis cerebral glucose metabolism fdg-pet cognition grey matter volume cognitively patients results behaviourally cerebral als metabolism impaired alsni alsci alscbi glucose Read moreHuo, Ong et al. present a comprehensive workflow to try to overcome key limitations in prior approaches for artificial intelligence (AI)-assisted prostate cancer Gleason grading. Their approach incorp...
intelligence cancer scanners pai artificial annotation pathologists approach model grading image prostate quality 0 images ai Read moreBreast cancer has been traditionally classified as either human epidermal growth factor receptor 2 (HER2)-positive or HER2-negative based on immunohistochemistry (IHC) scoring and/or gene amplificatio...
metastatic her2-negative therapy conjugates benefit patients defined her2 ihc cancer breast her2-low Read moreObjective To evaluate the efficacy and safety of the combination of camrelizumab and apatinib in the treatment of liver cancer and to furnish clinical recommendations for pharmacological interventions...
liver cancer camrelizumab apatinib meta-analysis adverse apatinib cancer liver meta-analysis safety camrelizumab combination ci 95% Read moreBackground The use of immune checkpoint inhibitors (ICIs) for the treatment of lung cancer may precipitate cardiotoxic events. We aimed to perform a meta-analysis to evaluate the cardiotoxicity associ...
immune checkpoint inhibitor cardiotoxicity cardiac adverse event chemotherapy lung cancer arrythmia heart failure significant [0 single = 0 compared chemotherapy cardiotoxicity lung patients cancer rr Read moreBackgrounds Microfibril-associated protein 2 (MFAP2) is a protein presenting in the extracellular matrix that governs the activity of microfibrils through its interaction with fibrillin. While the inv...
mfap2 triple-negative breast cancer (tnb... immunotherapy tumor mutational burden (tmb) pd-l1 immunotherapy breast genes correlation gene cancer analysis mfap2 tnbc cells Read morePancreatic cancer (PC) is mainly derived from the exocrine pancreatic ductal epithelial cells, and it is strongly aggressive malignant tumor. Due to its insidious onset and the lack of effective diagn...
pancreatic effect sponging cancer pro-cancer cells mechanism experiments mir-204-3p kras hsa_circ_0001846 Read moreBackground Prolonged postoperative ileus (PPOI) is a common complication after colorectal surgery that increases patient discomfort, hospital stay, and financial burden. However, predictive tools to a...
rectal cancer low anterior resection nomogram prolonged postoperative ileus cancer rectal postoperative low laparoscopic resection anterior curve ppoi nomogram Read moreBACKGROUND: Patient-Reported Outcome Measures (PROM) provide important information, however, missing PROM data threaten the interpretability and generalizability of findings by introducing potential b...
prom data random patient-reported characteristics demographic cancer-related crcs response missingness colorectal survivors cancer responders subsequent measures outcome non-responders generalizability missing initial day Read moreEffective surgical planning for breast cancer hinges on accurately predicting pathological complete response (pCR) to neoadjuvant chemotherapy (NAC). Diffusion-weighted MRI (DWI) and machine learnin...
breast cancer computer dwi 0 pcr Read moreBackground The preservation of the left colic artery (LCA) has emerged as a preferred approach in laparoscopic radical resection for rectal cancer. However, preserving the LCA while simultaneously dis...
preservation of left colic artery internal hernia no.253 lymph node dissection rectal cancer risk preservation laparoscopic defect ima ring sra tissue days left 0 colic median cancer postoperative internal artery hernia mesenteric lca rectal Read morePurpose Cancer treatments exert vascular toxic effects that can lead to the development of cardiovascular disease. Exercise training has the potential to prevent or reduce cancer treatment–induced dam...
neoplasms cardiotoxicity pulse wave analysis carotid intima-media thickness exercise physiology physical activity velocity effects meta-analyses cancer vascular training quality people studies exercise 0 Read moreBackground In current practice, rates of locally recurrent rectal cancer (LRRC) are low due to the use of the total mesorectal excision (TME) in combination with various neoadjuvant treatment strategi...
risk tme population-based patients os lrrc cancer treatment Read moreBackground MicroRNAs (miRNAs or miRs) are highly conserved non-coding RNAs with a short length (18–24 nucleotides) that directly bind to a complementary sequence within 3′-untranslated regions of thei...
mir-939 cancer diagnostic prognostic therapeutic target cancer mir-939 Read moreBackground Modifying public awareness of oesophageal cancer symptoms might help to decrease late-stage diagnosis and, in turn, improve cancer outcomes. This study aimed to explore oesophageal cancer s...
time cancer awareness oesophageal help-seeking dysphagia 0 anticipated Read moreBackground According to a phenomenology of contemporary religion, the analysis of religious experiences finds that they are part of an individual’s search for something powerful that overcomes him see...
spirituality religion phenomenology meaning of life palliative care oncology patients people cancer care meaning study experiences life Read moreThe mechanical properties and forces in the extracellular environment surrounding alveolar epithelial cells have the potential to modulate their behavior. Particularly, breathing applies 3-dimensional...
heparan stiffness chondroitin forces cancer targeting sulfate Read moreBackground: As a member of the mitochondrial ribosomal protein family, mitochondrial ribosomal protein L13 (MRPL13) is responsible for synthesizing mitochondrial proteins in cells. Several studies hav...
furthermore research protein mitochondrial cell relationship experiments luad level lung adenocarcinoma cancers expression cancer Read moreBackground Both IGF-1R/PI3K/AKT/mTOR and Hippo pathways are crucial for breast cancer stem cells (BCSCs). However, their interplay remains unclear. Methods Four triple negative breast cancer cell line...
hippo yap igf-1 igf-1r breast cancer stem cells localization level clinical interplay igf-1 breast cancer bcscs yap igf-1r Read moreCancer immunotherapy is an attractive strategy because it stimulates immune cells to target malignant cells by regulating the intrinsic activity of the immune system. However, due to lacking many immu...
cancer bacteria immune cells glioma Read moreHOOK3, a member of the human hook microtubule-tethering protein family, has been implicated in the progression of cancer. However, the role of HOOK3 in the pathogenesis of gastric cancer (GC) remains ...
invasion cancer migration study survival cells vegfa gc hook3 Read moreBackground Ovarian cancer (OC) typically develops an immunosuppressive microenvironment by funtional changes of host immune cells. Dysregulated m6A level is associated with cancer progression via the ...
mettl3 myeloid-derived suppressive cells tumor microenvironment inflammatory responses ovarian cancer m6a regulating progression id8 mice response role study cancer host m6a immune mettl3 cell secretion Read morePurpose Oral cancer is an underestimated health problem, and its existence and the relevant prevention measures are not sufficiently known by the general population. The project thus aimed to develop,...
oral cancer socio-economic status cancer awareness campaign early detection detection concept oral cancer target Read moreBackground Paraptosis is a programmed cell death characterized by cytoplasmic vacuolation, which has been explored as an alternative method for cancer treatment and is associated with cancer resistanc...
cancer paraptosis cyclin-dependent kinase 7/9 heat shock proteins reactive oxygen species nuclear stress protein kinase r stress hsps proteostatic paraptosis cancer Read morePurpose Tumor necrosis factor exerts many adverse biological effects, from cell proliferation to cell death. Accurate diagnosis and treatment are therefore difficult due to many factors influencing tu...
endometrial cancer tnf-α mirna tnf signaling expression profile factor related nfkb1 activity tnfr1 cav1 protein using expression tnf-α tumor necrosis cancer endometrial signaling Read moreBackground The Centers for Disease Control and Prevention launched the Colorectal Cancer Control Program to increase colorectal cancer screening among groups with low screening uptake. This engagement...
integrated interventions cancer screening disparities systems health manuscript approaches integrated program colorectal cancer Read moreWe explore threshold vocabulary trimming in Byte-Pair Encoding subword tokenization, a postprocessing step that replaces rare subwords with their component subwords. The technique is available in po...
vocabulary trimming subwords Read moreThere is evidence that the driving style of an autonomous vehicle is important to increase the acceptance and trust of the passengers. The driving situation has been found to have a significant infl...
pretrained found encoders computer data specific driving situation style behavior Read moreQuickly understanding lengthy lecture videos is essential for learners with limited time and interest in various topics to improve their learning efficiency. To this end, video summarization has bee...
summarization learning lecture information visual video science computer Read moreLarge pre-trained vision-language models such as CLIP provide compact and general-purpose representations of text and images that are demonstrably effective across multiple downstream zero-shot pred...
zero-shot computer learning representations Read moreWhile most recent advancements in legged robot control have been driven by model-free reinforcement learning, we explore the potential of differentiable simulation. Differentiable simulation promise...
legged differentiable using locomotion simulation Read moreThe importance of considering contextual probabilities in shaping response patterns within psychological testing is underscored, despite the ubiquitous nature of order effects discussed extensively ...
first-order study response Read moreThe graph and hypergraph container methods are powerful tools with a wide range of applications across combinatorics. Recently, Blais and Seth (FOCS 2023) showed that the graph container method is p...
container bound tester graph complexity Read moreTransfer learning is a de facto standard method for efficiently training machine learning models for data-scarce problems by adding and fine-tuning new classification layers to a model pre-trained o...
encrypted machine algorithm learning encryption transfer homomorphic Read moreIn this paper, we borrow the large language model (LLM) ChatGPT-3.5 to automatically and quickly design a new metaheuristic algorithm (MA) with only a small amount of input. The novel animal-inspire...
zso Read moreThis paper investigates guesswork over ordered statistics and formulates the complexity of ordered statistics decoding (OSD) in binary additive white Gaussian noise (AWGN) channels. It first develop...
sequences guesswork decoding osd statistics complexity Read moreIn this paper we present a deep learning pipeline for next day fire prediction. The next day fire prediction task consists in learning models that receive as input the available information for an a...
day task learning computer prediction fire Read moreWith the emergence of pre-trained vision-language models like CLIP, how to adapt them to various downstream classification tasks has garnered significant attention in recent research. The adaptation...
training-free networks adaptation few-shot training data memory science computer Read moreAs a digital environment of interconnected virtual ecosystems driven by measured and synthesized data, the Metaverse has so far been mostly considered from its gaming perspective that closely aligns...
applications advantages metaverse Read moreDescriptive grammars are highly valuable, but writing them is time-consuming and difficult. Furthermore, while linguists typically use corpora to create them, grammar descriptions often lack quantit...
extract grammar Read moreWe introduce InternVideo2, a new family of video foundation models (ViFM) that achieve the state-of-the-art results in video recognition, video-text tasks, and video-centric dialogue. Our core desig...
models understanding video Read moreThis work explores the zero-shot capabilities of foundation models in Visual Question Answering (VQA) tasks. We propose an adaptive multi-agent system, named Multi-Agent VQA, to overcome the limitat...
foundation models vqa multi-agent science computer Read moreModels such as GPT-4 and Med-PaLM 2 have demonstrated impressive performance on a wide variety of biomedical NLP tasks. However, these models have hundreds of billions of parameters, are computation...
trained models Read moreThe secure operation of the routing protocol is one of the major challenges to be met for the proliferation of the Mobile Ad hoc Networking (MANET) paradigm. Nevertheless, security enhancements have...
slsp Read moreInternational audience; We present a probabilistic algorithm to test if a homogeneous polynomial ideal I defining a scheme X in ℙn is radical using Segre classes and other geometric noti...
exponential Read moreShared gaze visualizations have been found to enhance collaboration and communication outcomes in diverse HCI scenarios including computer supported collaborative work and learning contexts. Given t...
intra-operative surgeons coordination instruction Read moreWe present a new method to automatically generate semantic segmentation annotations for thermal imagery captured from an aerial vehicle by utilizing satellite-derived data products alongside onboard...
data computer thermal segmentation semantic Read moreWe introduce in-context matting, a novel task setting of image matting. Given a reference image of a certain foreground and guided priors such as points, scribbles, and masks, in-context matting ena...
foreground iconmatting matting Read moreWe present a corpus of 100 documents, OBSINFOX, selected from 17 sources of French press considered unreliable by expert agencies, annotated using 11 labels by 8 annotators. By collecting more label...
french Read moreLumbar disc degeneration, a progressive structural wear and tear of lumbar intervertebral disc, is regarded as an essential role on low back pain, a significant global health concern. Automated lumb...
networks science $\textit{transdeformer}$ lumbar computer Read moreGeolocating precise locations from images presents a challenging problem in computer vision and information retrieval.Traditional methods typically employ either classification, which dividing the E...
models computer img2loc Read moreBackground China was the last country in the world to relax COVID-19 restrictions. A successful public health policy requires public support. This analysis examined the factors associated with Chinese...
covid-19 policy support china covid fatigue fatalism cultural values covid fatigue results collectivism policy positively predicted china negatively public liberty support restrictions zero-covid relaxing Read moreObjective To examine the relationship between physical rehabilitation parameters including an approach to quantifying dosage with hospital outcomes for patients with critical COVID-19. Design Retrospe...
physical rehabilitation early mobilization critical illness occupational therapy physical therapy covid outcomes care < 0 am-pac covid-19 physical hospital 001 Read moreBackground Studies estimate that at least 7.5% of adults are affected by long-term symptoms such as fatigue or cognitive impairment after the acute phase of COVID-19. COVID-19 vaccination may reduce t...
long covid sars-cov-2 covid-19 vaccination rehabilitation germany qualitative study experiences symptoms qualitative people covid participants vaccination study covid-19 reported Read moreBackground China was the last country in the world to relax COVID-19 restrictions. A successful public health policy requires public support. This analysis examined the factors associated with Chinese...
covid-19 policy support china covid fatigue fatalism cultural values covid fatigue results collectivism policy positively predicted china negatively public liberty support restrictions zero-covid relaxing Read moreBACKGROUND: Post-acute sequelae of SARS-CoV-2, referred to as “long COVID”, are a globally pervasive threat. While their many clinical determinants are commonly considered, their plausible social corr...
health sex adjusted covid qalds life quality 100% research uk clinical Read moreSince the outbreak in Wuhan (China) at the end of 2019, the Coronavirus Disease 2019 (COVID-19) pandemic has caused instability at various levels of society. While most patients completely recover fro...
long covid covid-19 sars-cov-2 quality of life oncology study impact infection patients covid cancer Read morePurpose To evaluate the impact of the COVID-19 pandemic on renal cell carcinoma (RCC) care in the Netherlands. Methods Newly diagnosed RCCs between 2018 and 2021 were selected from the Netherlands Can...
covid-19 renal cell carcinoma incidence disease stage treatment 2021 evaluate care wave pandemic covid-19 covid rccs Read moreBackground The COVID-19 pandemic further propelled the recent growth of telemedicine in low-resource countries, with new models of telemedicine emerging, including volunteer-based telemedicine network...
telemedicine volunteerism medical providers incentives covid india stated volunteer-based maintain financial practitioners health networks covid-19 incentives pandemic Read moreBACKGROUND: Severe COVID and multisystem inflammatory syndrome (MIS-C) are characterized by excessive inflammatory cytokines/chemokines. In adults, disease severity is associated with SARS-CoV-2-speci...
pediatric bulk adults spike inflammatory fc igg following vaccination adult covid glycosylation Read moreBackground China was the last country in the world to relax COVID-19 restrictions. A successful public health policy requires public support. This analysis examined the factors associated with Chinese...
covid-19 policy support china covid fatigue fatalism cultural values covid fatigue results collectivism policy positively predicted china negatively public liberty support restrictions zero-covid relaxing Read moreBackground Pain is one of the prevalent Long COVID Symptoms (LCS). Pain interferes with the quality of life (QoL) and induces disease burden. Purpose The study aimed to elicit the clinical presentatio...
long covid pain quality of life bangladesh study bangladesh 1% pain 95% ci covid quality life Read moreBackground In December 2019, a cluster of patients with pneumonia of undetermined etiology was recognized in Wuhan, Hubei, China. Subsequently, a novel coronavirus (Severe Acute Respiratory Distress S...
git symptoms covid 19 diarrhea nausea vomiting coronavirus severe respiratory tract clinical symptoms covid 19 patients covid-19 rectal pcr manifested Read moreBackground Public transportation plays a major role in the transmission of SARS-CoV2, the virus that causes COVID-19, due to the confined spaces in vehicles. It is therefore very crucial to apply COVI...
covid-19 public transportation public transport operators covid-19 preventive measures study risk eastern uganda epidemic aware included interviews participants awareness perceptions public transportation covid-19 perceived covid passengers barriers operators challenges 19 preventive transmission transport measures Read moreMany conventional research methods employed in randomized controlled trials were not possible during the height of the COVID-19 pandemic. In particular, behavioral observations are nearly universally ...
observational research observational methodology parenting covid military families parenting in-person reliability methods collected collection observational data remote Read moreBackground The COVID-19 pandemic further propelled the recent growth of telemedicine in low-resource countries, with new models of telemedicine emerging, including volunteer-based telemedicine network...
telemedicine volunteerism medical providers incentives covid india stated volunteer-based maintain financial practitioners health networks covid-19 incentives pandemic Read moreBackground Most studies on the impact of the COVID-19 pandemic on depression burden focused on the earlier pandemic phase specific to lockdowns, but the longer-term impact of the pandemic is less well...
depression incidence health resource utilization health service use covid pandemic interrupted time series electronic medical records cohort study 2022 healthcare patients covid-19 pandemic incidence Read moreMany conventional research methods employed in randomized controlled trials were not possible during the height of the COVID-19 pandemic. In particular, behavioral observations are nearly universally ...
observational research observational methodology parenting covid military families parenting in-person reliability methods collected collection observational data remote Read moreBackground China was the last country in the world to relax COVID-19 restrictions. A successful public health policy requires public support. This analysis examined the factors associated with Chinese...
covid-19 policy support china covid fatigue fatalism cultural values covid fatigue results collectivism policy positively predicted china negatively public liberty support restrictions zero-covid relaxing Read moreBackground Oxidative stress, an imbalance between reactive oxygen species production and antioxidant capacity, increases in patients with coronavirus disease (COVID-19) or renal impairment. We investi...
covid-19 oxidative stress reactive oxygen species hemodialysis end-stage renal disease < 0 disease covid covid-esrd renal covid-19 esrd patients 001 Read moreSince the outbreak in Wuhan (China) at the end of 2019, the Coronavirus Disease 2019 (COVID-19) pandemic has caused instability at various levels of society. While most patients completely recover fro...
long covid covid-19 sars-cov-2 quality of life oncology study impact infection patients covid cancer Read morePurpose This longitudinal study investigated distress rates in patients with advanced ovarian cancer during the COVID-19 pandemic and examined whether time, illness representations, and coping strateg...
ovarian cancer distress fear of progression coping perceptions covid advanced levels patients cancer ovarian coping Read moreObjective To examine the relationship between physical rehabilitation parameters including an approach to quantifying dosage with hospital outcomes for patients with critical COVID-19. Design Retrospe...
physical rehabilitation early mobilization critical illness occupational therapy physical therapy covid outcomes care < 0 am-pac covid-19 physical hospital 001 Read moreBackground Pain is one of the prevalent Long COVID Symptoms (LCS). Pain interferes with the quality of life (QoL) and induces disease burden. Purpose The study aimed to elicit the clinical presentatio...
long covid pain quality of life bangladesh study bangladesh 1% pain 95% ci covid quality life Read moreLong COVID is characterized by persistent symptoms, particularly pulmonary impairment, which necessitates advanced imaging for accurate diagnosis. Hyperpolarised Xenon-129 MRI (XeMRI) offers a promi...
covid alignment data multimodal registration Read moreTelogen effluvium is characterized by excessive hair shedding usually following a stressful event. Ferritin has been used in clinical practice as a biomarker of nonanemic iron deficiency in cases of t...
covid postcovid telogen effluvium ferritin biomarkers vitamin d vitamin c zinc lactoferrin ivermectin azithromycin significantly biomarker study ferritin patients value Read moreBackground Early diagnosis of HIV infection decreases the time from HIV diagnosis to viral suppression and reduces further HIV transmission. The Chinese Guidelines for the Diagnosis and Treatment of H...
hiv low viral load values diagnosis acute hiv infection 2434 antibody results patients hiv load infection confirmatory diagnosis values Read moreBackground This exploratory analysis investigates the prevalence and risk factors of neurocognitive toxicity in postpartum women on HIV treatment in response to a concern of an Isoniazid Preventive Th...
depression isoniazid preventive therapy efavirenz pregnant and breastfeeding women phq-9 ipt treatment hiv neuropathy peripheral depression prevalence sleep quality cognitive symptoms postpartum women Read moreBackground Immune reconstitution inflammatory syndrome (IRIS) is a complex phenomenon commonly diagnosed with human immunodeficiency virus (HIV). However, rarely, IRIS can develop with other diseases ...
immune reconstitution inflammatory... pneumonia solid organ transplant hiv iris Read moreBACKGROUND: While existing research on people living with HIV (PWH) during the COVID-19 pandemic primarily focused on their clinical outcomes, a critical gap remains in understanding the implications ...
patients non-covid-19 hospitalisation city mexico pandemic advanced p < 0 01 hospitalisations outcomes pwh compared causes characteristics hiv covid-19 vs 2020 Read moreBackground Exclusive breastfeeding (EBF) in the first six months remains low globally, despite known benefits of lower morbidity and mortality among breastfed infants. It is important to understand fa...
exclusive breastfeeding women living with hiv hiv-exposed uninfected children immunization visits breastfeeding sub-saharan africa infant 6-months apr 95% ci women lower 0 breastfeeding prevalence wlwh hiv ebf Read moreHIV infection leads to an early deregulation of immune responses causing ineffective adaptive responses associated with disease progression. In this regard, dendritic cells (DCs) play a...
model adaptive modèle pré-dcs infection pre-dcs hiv siv au réponses responses vivo Read moreINTRODUCTION: Globally, the incidence of HIV and syphilis can be reduced by the use of validated point of care tests (POCTs). As part of the WHO PRoSPeRo Network, we aimed to evaluate the performance,...
msm bioline positive chembio reactive rpr acceptability pocts syphilis dual characteristics operational hiv Read moreErythema multiforme (EM) is an immune-mediated mucocutaneous condition characterized by hypersensitivity reactions to antigenic stimuli from infectious agents and certain drugs. The most commonly impl...
hiv erythema multiforme adverse drug reactions haart polypharmacy mucocutaneous lesions virus epithelial infections opportunistic hypersensitivity reactions cd8 + t cells trigger individuals hiv-infected hiv Read moreBrief tools are necessary to identify adolescents at greatest risk for ART non-adherence. From the WHO’s HEADSS/HEADSS+ adolescent wellbeing checklists, we identify constructs strongly associated with...
adolescents hiv aids mental health health personnel treatment health p < 0 001 ci aor adolescents risk Read moreBackground Globally transgender women (TW) are at heightened vulnerability for HIV infection. In Lima Peru, sharp increases in HIV prevalence are seen among TW ages 25 years and older highlighting the...
hiv prevention transgender latin america youth lima vulnerability violence social conducted life development peru hiv tw Read moreBackground Maternal knowledge on mother-to-child transmission (MTCT) and its prevention has been identified to enhance maternal testing and adherence to antiretroviral therapy (ART) regimen. Examining...
reproductive age sub-sharan africa vertical transmission counseling antiretroviral treatment mother-to-child transmission hiv hiv analysis conducted childbearing survey mtct knowledge aor = 1 prevention 95% ci = 1 health Read moreHalf of all people living with HIV (PLWH) in the United States are not retained in HIV medical care. The utility of appointment reminders and clinic-based retention support services is often limited b...
hiv communication care peer plwh plwh-ooc outreach preferences Read moreBackground The world is moving towards the third target of the Joint United Nations Programme on HIV/AIDS to ensure most people receiving antiretroviral therapy (ART) are virologically suppressed. Lit...
undetectable viral load viral suppression viral rebound 95% antiretroviral therapy hospital study vr people level clinic ci tanzania participants vl visits suppression risk hiv undetectable art Read moreBackground Sexual uses of alcohol and drugs are pervasive among men who have sex with men (MSM) and associated with increased risk of HIV infection. However, there are limited studies related to sexua...
alcohol drug multi-drug use hiv men who have sex with men infection reporting sex aor = 2 hiv china msm drug Read moreHIV remains a significant public health issue among young adults living in Uganda. There is a need for reliable and valid measures of key psychological and behavioural constructs that are related to i...
measures hiv young adults uganda validity validity preliminary measures Read moreIntroduction People who use drugs (PWUD) are at increased risk for HIV infection. HIV self-testing (HIVST) is a promising method for identifying new infections, but optimal distribution strategies rem...
hiv/aids hiv self-testing people who use drugs harm reduction syringe services program ehe strategies ci via pwud cisgender hivst 95% mail peers distribution hiv 0 received vs testing Read morePurpose People living with HIV (PLHIV) have reported challenges associated with daily oral antiretroviral therapy (ART), including missed doses, negative psychological impact, and difficulty remaining...
health state utility treatment process utility utility route of administration hiv antiretroviral therapy long-acting injectable associated process vs utility hiv daily injections art oral lai treatment Read moreObjectives The primary objective was to evaluate the safety of the anti-PD-1 antibody camrelizumab in people living with HIV (PLWH); the secondary objective was to evaluate tumor response. Methods Fro...
immune checkpoint inhibitor people living with hiv advanced cancers camrelizumab tumor response hiv camrelizumab cancer safety Read moreIntroduction Key and priority populations (with risk behaviours and health inequities) are disproportionately affected by HIV in Uganda. We evaluated the impact of an intensive case management interve...
antiretroviral therapy retention in care key populations viral suppression hiv approximately hiv p = 0 03 phases pre-intervention management 0 participants outcomes phase 6-month intervention retention Read moreBACKGROUND: As persons with HIV (PWH) live longer they may experience a heightened burden of poor health. However, few studies have characterized the multi-dimentional health of PWH. Thus, we aimed to...
17 8% 69 disparities 23 84 7% 4% 95% ci infection hiv health Read moreBACKGROUND: Sexually transmitted infections (STIs) such as syphilis and HIV remain to be a significant public health issue worldwide. Dual rapid point-of-care tests (POCTs) have shown promise for dete...
test rpr point-of-care demonstrated dts tp-pa assay quality testing panels 7% cdc hiv/syphilis study laboratories hiv agreement eqa using clinical Read moreIntroduction and importance Pneumocystis jirovecii (PJP) pneumonia is a serious life-threatening condition in immunocompromised individuals and is often associated with human immunodeficiency virus (H...
pneumocystis pneumonia hiv immunocompromised infection diagnosis despite therapy appropriate factors pneumonia pjp Read moreINTRODUCTION: There is a high burden of hypertension (HTN) among HIV-infected people in Uganda. However, capacity to prevent, diagnose and treat HTN is suboptimal. This study seeks to leverage the exi...
hiv randomised ethics trial hfs care htn study Read moreBACKGROUND: Although indicator condition (IC)-guided HIV testing (IC-HIVT) is effective at facilitating timely HIV diagnosis, research on IC categories and the related HIV risk in Taiwan is limited. T...
taiwan associated study research ic-hivt category ics diagnosis ic hiv Read moreUnderstanding the impact of disease associations is becoming a priority in Kenya and other countries bearing the load of infectious diseases. With the increased incidences of non-communicable diseases...
study diseases glucose mellitus associated diabetes patients hiv Read more[Image: see text] Sialidases or neuraminidases are sialic-acid-cleaving enzymes that are expressed by a broad spectrum of organisms, including pathogens. In nature, sialic acids are monosaccharides wi...
7-n-acetyl influenza neuraminidases probes Read moreBackground The 2009 H1N1 influenza pandemic (influenza A(H1N1)pdm09) disproportionately impacted Indigenous peoples. Indigenous Australians are also affected by a health gap in chronic disease prevale...
conditions ratios rate australian population disease chronic influenza health amongst prevalence severity non-indigenous indigenous Read moreBackground Common air pollutants such as ozone (O_3), sulfur dioxide (SO_2), nitrogen dioxide (NO_2), and particulate matter play significant roles as influential factors in influenza-like illness (IL...
influenza transmissibility flu ozone significant u-shaped regions $${r}_{t}$$ influenza Read moreOBJECTIVES: To examine inpatient vaccine delivery across a national sample of children’s hospitals. METHODS: We conducted a retrospective cohort study examining vaccine administration at 49 children’s...
children’s vaccines hepatitis influenza children administered hospitalizations hospitals Read moreAs for the case of SARS-CoV-2, genome sequencing of influenza viruses is of potential interest to raise and address virological issues. Recently, false-negativity of real-time reverse t...
2a 93 commercialized influenza genomes clade qpcr 2a1b 3c virus assays Read moreOBJECTIVE: To evaluate the effectiveness of reminder letters informed by social normative theory (a type of ‘nudge theory’) on uptake of seasonal influenza vaccination by front-line hospital staff. DE...
front-line norm vaccine influenza seasonal uptake injunctive descriptive norms staff 0 letter social Read moreBackground In China, the national prevalence of parental influenza vaccine hesitancy (IVH) during the pandemic of coronavirus disease 2019 (COVID-19), and the association between risk perception and p...
vaccine hesitancy influenza china reproductive women covid-19 pandemic covid-19 aor = 2 low national association perceived risk perception benefit moderate children china ci 95% ivh barriers vaccine hesitancy women Read moreInternational audience; Background: Influenza has been shown to increase the risk for severe bacterial infection, in the tropics the seasonality of influenza epidemics is less marked, an...
monthly bacterial sepsis influenza dengue Read moreBACKGROUND: Common air pollutants such as ozone (O(3)), sulfur dioxide (SO(2)), nitrogen dioxide (NO(2)), and particulate matter play significant roles as influential factors in influenza-like illness...
regions significant u-shaped humidity text] [formula influenza association Read moreInternational audience; Abstract For >70 years, a 4-fold or greater rise in antibody titer has been used to confirm influenza virus infections in paired sera, despite recognition that th...
infection hai antibody virus influenza Read morePurpose of Review To review the recent literature surrounding immune responses to influenza vaccination in solid organ transplant (SOT) recipients, in addition to reviewing future directions for novel...
influenza vaccination solid organ transplant immunogenicity adjuvant booster mrna responses directions future doses booster vaccines organ transplant vaccination immune population influenza Read moreStructural studies of a computationally optimized broadly reactive antigen hemagglutinin in complex with a broadly neutralizing antibody reveal its immunogenic properties and provide insights into flu...
computationally influenza vaccine hemagglutinin optimized cobra Read moreBACKGROUND: Seasonal influenza epidemics yearly affects 5–15% of the world’s population, resulting in 3–5 million serious cases and up to 650,000 deaths. According to the 2017–2019 Italian National Im...
rates 2011/2012 immunisation influenza heart chronic Read moreA case report of highly pathogenic avian influenza A H5N1 of clade 2.3.4.4b in the brain of a common bottlenose dolphin (Tursiops truncatus) from Florida, United States. Since late 2021, highly pathog...
influenza hpai united highly pathogenic h5n1 avian Read moreHost lipid composition influences many stages of the influenza A virus (IAV) entry process, including initial binding of IAV to sialylated glycans, fusion between the viral envelope and the host membr...
host virus influenza efficiency membrane cholesterol lipid mixing target fusion Read moreInternational audience; Influenza virus transcription is catalyzed by the viral RNA-polymerase (FluPol) through a cap-snatching activity. The snatching of the cap of cellular mRNA by Flu...
host domains virus rna-polymerase transcription influenza flupol ii pol domain rpb4 Read moreSegment sequences can be found on GenBank (accession numbers MK859904 to MK859911 and MK859926 to MK859933).;International audience; ABSTRACT H5N8 high-pathogenicity avian influenza viru...
lesions contrast inflammatory cause infection duck distress replication neurotropism neurological signs influenza h5n8 virus chickens ducks viral Read moreInternational audience; Background: Lung reactivations of Herpesviridae, herpes simplex virus (HSV) and cytomegalovirus (CMV) have been reported in COVID-19 patients. Whether or not thos...
virus respectively similar patients severe lung influenza pneumonia reactivations hsv covid-19 Read moreIntracellular pathogens interact with host factors, exploiting those that enhance replication while countering those that suppress it. Genetic screens have begun to define the host:pathogen interface ...
factors influenza screen screens host dna infection trex1 Read moreStructural studies of a computationally optimized broadly reactive antigen hemagglutinin in complex with a broadly neutralizing antibody reveal its immunogenic properties and provide insights into flu...
computationally influenza vaccine hemagglutinin optimized cobra Read moreBackground: Procalcitonin (PCT) and C-Reactive protein (CRP) are well-established sepsis biomarkers. The association of baseline PCT levels and mortality in pneumonia remains unclear, and we still do ...
severe influenza patients bc compared mortality pvp biomarkers 0 pneumonia [0 crp versus levels Read moreBackground Acute myocardial injury is associated with poor prognosis in respiratory tract infections. We aimed to highlight the differences in prevalence of myocardial injury and its impact on prognos...
covid-19 prognosis seasonal influenza cardiovascular disease prognosis covid-19 significantly seasonal myocardial injury influenza Read moreBackground Healthcare workers (HCWs), such as doctors, nurses, and support staffs involved in direct or indirect patient care, are at increased risk of influenza virus infections due to occupational e...
influenza vaccination influenza vaccine awareness healthcare worker knowledge and perceptions barriers and motivators policymakers' views care bangladesh influenza vaccine hcws vaccination intervention study Read moreTargeting surveillance resources toward individuals at high risk of early infection can accelerate the detection of emerging outbreaks. However, it is unclear which individuals are at high risk withou...
health individuals acquaintance random influenza method infection covid-19 peak warning surveillance strategy ehr-based Read moreBackground Many concerns regarding respiratory diseases, including influenza, emerged during the epidemic of COVID-19. There were relevant research findings and suggestions for influenza prevention an...
influenza physical activity prevention and treatment exercise prescription search treatment beneficial viruses studies human physical activity prevention Read moreBackground While the human oral microbiome is known to play an important role in systemic health, its average composition and diversity patterns are still poorly understood. To gain better insights in...
oral microbiota oral microbiome saliva exome sequencing metagenomics socio-economic status subsistence methods african populations Read moreBackground Burkholderia pyrrocinia strain P10 is a plant growth-promoting rhizobacterium (PGPR) that can substantially increase peanut growth. However, the mechanisms and pathways involved in the inte...
pgpr root exudates growth-promoting mechanisms biofilm formation pgpr interaction genes acids expression iaa secretion pyrrocinia re strain effects growth-promoting p10 peanut Read moreDiabetes mellitus (DM) is a chronic metabolic disorder characterized by an elevated level of blood glucose due to the absence of insulin secretion, ineffectiveness, or lack of uptake of secreted insul...
diabetes mellitus magnesium supplementation probiotic cfu 5 × 10^5 basal diabetes study standard rats dysbiosis diet provided blood butyricum clostridium glucose Read moreBackground Gut microbiota dysbiosis is associated with the development of non-alcoholic steatohepatitis (NASH) through modulation of gut barrier, inflammation, lipid metabolism, bile acid signaling an...
hyperglucagonemia scfa ph colon microbiota bile acids imidazole propionate imidazole development associated propionate addition dysbiosis cdahfd gut microbiota nash Read moreBackground Hashimoto’s thyroiditis (HT) is an autoimmune disease. Recent studies have found that the gut microbiota may play an important role in inducing HT, but there are no systematic studies on th...
hashimoto’s thyroiditis gut microbiota 16s rdna high-throughput sequencing biomarkers studies hca gut microbiota ht Read moreBackground Intra-oral halitosis (IOH) is bad breath produced locally by the mouth in addition to systemic diseases and is one of the main causes of interpersonal communication and psychological disord...
intra-oral halitosis oral flora flora imbalance microbiota transplantation 16srrna gene sequencing picrust metabolic analysis feasibility salivary associated significantly baseline transplantation < 0 values wistar ioh treatment compared metabolic microbiota oral test flora Read moreBackground Mangrove sediment microbes are increasingly attracting scientific attention due to their demonstrated capacity for diverse bioremediation activities, encompassing a wide range of environmen...
metagenomic analysis 16s rrna mangrove sediment organohalides bioremediation community organohalide sediment picrust diverse ohr reductive mangrove sediments Read moreBackground Probiotics can reduce free radical scavenging rate and oxidative damage, and improve activity of crucial antioxidative enzymes in host cells. This study aimed to isolate Bifidobacterium spp...
antioxidant anti-aging levels t37a antioxidant liver Read moreBackground Endophytic Aspergillus species produce countless valuable bioactive secondary metabolites. In the current study, Aspergillus flavus an endophyte from the soft coral Sarcophyton ehrenbergi...
in silico profile antimicrobial anticancer endophyte dynamic simulation nmr spectroscopy mic endophytic flavus ml compounds antimicrobial activity Read moreAt particular stages during their life cycles, fungi use multiple strategies to form specialized structures to survive unfavorable environmental conditions. These strategies encompass sporulation, as ...
fungi lysis-resistance extreme environment spores lake sediments microbial mats seed fraction bank strategies fungal lysis-resistant structures diversity environment microbial Read moreBackground Female reproductive tract infection (RTI) is the common source of varied diseases, especially as an important risk factor for pregnancy outcomes, therefore the rapid, accurate and simultane...
reproductive tract infection pathogen loop-mediated isothermal amplifica... microfluidic technology lamp-microfluidic chip rapid and simultaneous detection female tract pregnancy positive tube lamp rapid simultaneous chip lamp-microfluidic pathogens rti samples method detection clinical Read moreAntimicrobial peptides, such as bacteriocin, produced by probiotics have become a promising novel class of therapeutic agents for treating infectious diseases. Selected lactic acid bacteria (LAB) isol...
antibacterial activity bacteriocin-like inhibitory substa... biofilm formation multidrug-resistant bacteria probiotic antibacterial genome aeruginosa strains blis cylb30 cylb47 Read moreObesity is a metabolic disorder closely associated with profound alterations in gut microbial composition. However, the dynamics of species composition and functional changes in the gut microbiome in ...
obesity gut microbiota metagenomics microbiome virome ruminococcus eubacterium species obesity gut Read moreBackground The genomic information available for Pediococcus pentosaceus is primarily derived from fermented fruits and vegetables, with less information available from fermented meat. P. pentosaceus ...
whole-genome sequencing exopolysaccharide comparative genomics meat genes experiments genomic probiotic fermented Read moreBackground In investigating of (exopolysaccharide) EPS from unconventional sources, lactic acid bacteria have a vital role due to their generally recognized as safe (GRAS) status. EPSs have diverse ap...
probiotic lactic acid bacteria exopolysaccharide optimization response surface methodology yield study eps rsm experimental reps plantarum ro30 Read moreBackground Data about the prevalence of plasmid-mediated quinolone resistance (PMQR) and extended-spectrum beta-lactamase (ESBL) production in P . aeruginosa compared to the Enterobacteriaceae family ...
fluoroquinolones pmqr esbl egypt fluoroquinolone-resistant significant correlation 3% followed detected -ib-cr acc esbl gene Read moreBackground Allergic rhinitis (AR) is characterized by airway inflammation in nasal mucosa from inhaled allergens and interleukin (IL)-33 is the potent inducer of Th2 inflammation in allergic nasal epi...
allergic rhinitis interleukin-33 necroptosis nasal epithelium arne cellular nasal il-33 epithelium inflammation necroptosis cells th2 ar epidermidis production allergic Read moreBackground The floc is a characteristic of microbial aggregate growth, displaying cloudy suspensions in water. Floc formation has been demonstrated in a series of bacteria and the floc-forming bacteri...
bacterial floc formation pep-cterm proteins flocculation rpon sigma factor pep-cterm bacteria floc formation Read moreBackground Colorectal cancer (CRC) is a prevalent malignant malignancy affecting the gastrointestinal tract that is usually treated clinically with chemotherapeutic agents, whereas chemotherapeutic ag...
colorectal cancer irinotecan intestinal microbiota gastrointestinal toxicity agents chemotherapeutic signaling effect pathway vs effects gastrointestinal crc sx-1326 longum Read moreWith almost 700 000 estimated cases each year in the United States and Europe, Lyme borreliosis (LB), also called Lyme disease, is the most common tick-borne illness in the world. Transmitted by ticks...
lyme disease tick diagnostic culture pcr serology detection, direct and ind... lb detection Read moreBackground Macrolide antibiotics have been extensively used for the treatment of Staphylococcus aureus infections. However, the emergence of macrolide-resistant strains of S. aureus has become a major...
mechanisms azithromycin erythromycin aureus molecular k_3 staphylococcus macrolide isolates Read morePurpose Yeast strains tolerant to a wide range of stress conditions are needed for the production of bioethanol from substrates rich in sugar. In our earlier research findings, Meyerozyma caribbica is...
yeast optimization response surface method fermentation molasses bioethanol surface rate using mixing predicted ethanol bioethanol concentration isolate mjtm3 production l^−1 caribbica yield molasses conditions Read moreBackground and objectives Microbial cells capability to tolerate the effect of various antimicrobial classes