Day selection 12/22/2024

IL-3 is a hemopoietic growth factor that usually targets blood cell precursors; IL-3R is a cytokine receptor that binds to IL-3. However, IL-3 takes on a different role in the context of glial cells...

Brain-related diseases are more sensitive than other diseases due to several factors, including the complexity of surgical procedures, high costs, and other challenges. Alzheimer's disease is a comm...

Semantic fluency tests have been widely used as a screening test for dementia of Alzheimer type. However, few studies have explored the application of semantic fluency tests in Mandarin Chinese speake...

The amyloid-β (Aβ) peptides, which accumulate in amyloid plaques, are formed by canonical cleavages of the amyloid precursor protein (APP) by β- and γ-secretases. Under physiological co...

This study aimed to develop new equations to estimate cardiorespiratory fitness specifically for older adults and, secondly, to analyze the associations of cardiorespiratory fitness, both objectively ...

We present our submission to the ICASSP-SPGC-2023 ADReSS-M Challenge Task, which aims to investigate which acoustic features can be generalized and transferred across languages for Alzheimer's Disea...

APOE ^ ε4 is the major genetic risk factor for sporadic Alzheimer’s disease (AD). Although APOE ^ ε4 is known to promote Aβ pathology, recent data also support an effect of  APOE  polymorphism on phos...

Alzheimer's Disease (AD) is primarily an irreversible neurodegenerative disorder affecting millions of individuals today. The prognosis of the disease solely depends on treating symptoms as they ari...

Automated diagnosis of Alzheimer Disease(AD) from brain imaging, such as magnetic resonance imaging (MRI), has become increasingly important and has attracted the community to contribute many deep l...

Alzheimer's Disease is a devastating neurological disorder that is increasingly affecting the elderly population. Early and accurate detection of Alzheimer's is crucial for providing effective treat...

International audience; The link between Alzheimer's disease (AD) and network hypersynchrony-manifesting as epileptic activities-received considerable attention in the past decade. Howev...

Disinhibition during early stages of Alzheimer's disease is postulated to cause network dysfunction and hyperexcitability leading to cognitive deficits. However, the underlying molecular mechanism rem...

Insoluble fibrillar tau, the primary constituent of neurofibrillary tangles, has traditionally been thought to be the biologically active, toxic form of tau mediating neurodegeneration in Alzheimer’s ...

Nearly fifty million older people suffer from neurodegenerative diseases, including Alzheimer (AD) and Parkinson (PD) disease, a global burden expected to triple by 2050. Such an imminent “neurologica...

International audience; Alzheimer's disease and related dementia (ADRD) are characterized by multiple and progressive anatomo-clinical changes including accumulation of abnormal proteins...

Brain-related diseases are more sensitive than other diseases due to several factors, including the complexity of surgical procedures, high costs, and other challenges. Alzheimer's disease is a comm...

An interpretable machine learning (ML) framework is introduced to enhance the diagnosis of Mild Cognitive Impairment (MCI) and Alzheimer's disease (AD) by ensuring robustness of the ML models' inter...

Background A positive effect of the effect of a 3-month oral spermidine intake on memory performance has already been demonstrated. The continuation of this study aimed to examine whether there could ...

Alzheimer's disease (AD) is the leading cause of dementia, and its early detection is crucial for effective intervention, yet current diagnostic methods often fall short in sensitivity and specifici...

Alzheimer's disease is a common cognitive disorder in the elderly. Early and accurate diagnosis of Alzheimer's disease (AD) has a major impact on the progress of research on dementia. At present, re...

Brain development and maturation leads to grey matter networks that can be measured using magnetic resonance imaging. Network integrity is an indicator of information processing capacity which decline...

Finding effective disease‐modifying treatment for Alzheimer's disease remains challenging due to an array of factors contributing to the loss of neural function. The current study demonstrates a new s...

Background We investigated the phenotypes and genotypes of a cohort of ‘long-surviving’ individuals with motor neuron disease (MND) to identify potential targets for prognostication. Methods Patients ...

The stimulator of interferon genes (STING) pathway has been implicated in neurodegenerative diseases, including Parkinson’s disease and amyotrophic lateral sclerosis (ALS). While prior studies have fo...

Objective To characterize the participant demographics in the Pooled Resource Open-Access ALS Clinical Trials (PRO-ACT) database compared with the web-portal National Amyotrophic Lateral Sclerosis (AL...

Objective There is increasing evidence that amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease impacting large-scale brain networks. However, it is still unclear which stru...

Protein homeostasis, or proteostasis, is essential for cell function and viability. Unwanted, damaged, misfolded and aggregated proteins are degraded by the ubiquitin–proteasome system (UPS) and the a...

Background There is an unmet need in amyotrophic lateral sclerosis (ALS) to provide specific biomarkers for the disease. Due to their easy availability, we aimed to investigate whether routine blood p...

Background Plasma exchange (PE) is used to treat a range of neurological disorders. Based on results demonstrated in Alzheimer’s disease, we theorized that PE with albumin replacement (PE-A) might alt...

Background Recent evidence points toward a role of the small ubiquitin-like modifier (SUMO) system, including SUMO4, in protecting from stress insults and neurodegeneration, such as the progressive mo...

Objective Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disorder associated with progressive loss of motor neurons. It is a growing and underestimated disease, prompting this epidem...

The stimulator of interferon genes (STING) pathway has been implicated in neurodegenerative diseases, including Parkinson’s disease and amyotrophic lateral sclerosis (ALS). While prior studies have fo...

Background and objectives Primary lateral sclerosis (PLS) is a motor neuron disease characterised by loss of the upper motor neurons. Most patients present with slowly progressive spasticity of the le...

Biallelic pathogenic repeat expansions in RFC1 were recently identified as molecular origin of cerebellar ataxia, neuropathy, vestibular areflexia syndrome (CANVAS) as well as of one of the most commo...

Amyotrophic lateral sclerosis (ALS) is a progressive neurodegenerative disease characterized by selective, early degeneration of motor neurons in the brain and spinal cord. Motor neurons have long axo...

A central event in the pathogenesis of motor neuron disease (MND) is the loss of neuromuscular junctions (NMJs), yet the mechanisms that lead to this event in MND remain to be fully elucidated. Mainte...

Lipids, defined by low solubility in water and high solubility in nonpolar solvents, can be classified into fatty acids, glycerolipids, glycerophospholipids, sphingolipids, and sterols. Lipids not onl...

Objectives The aim of this study was to assess and compare the diagnostic utility of a new diagnostic criteria for amyotrophic lateral sclerosis (ALS), abbreviated as the ‘Gold Coast Criteria’, with t...

Background A single cycle (two repeated treatments) with intrathecal autologous bone marrow-derived mesenchymal stem cells (BM-MSCs, 26-day interval) showed safety and provided therapeutic benefit las...

[Objective] Few studies have comprehensively investigated the non-motor symptoms of amyotrophic lateral sclerosis (ALS). We aimed to investigate this aspect of ALS. [Methods] We held a nationwide webi...

The most common genetic cause of familial and sporadic amyotrophic lateral sclerosis (ALS) is a GGGGCC hexanucleotide repeat expansion (HRE) in the C9orf72 gene. While direct molecular hallmarks of th...

Amyotrophic lateral sclerosis (ALS) is the most common subtype of motor neuron disease (MND). The current gold-standard measure of progression is the ALS Functional Rating Scale—Revised (ALS-FRS(R)), ...

Background People with amyotrophic lateral sclerosis (ALS) are at high risk for severe outcomes from Covid-19 infection. Researchers exploring ALS and Covid-19 have focused primarily on system respons...

Amyotrophic lateral sclerosis (ALS) is a rapidly progressive and fatal neurodegenerative disorder, characterized by selective loss of motor neurons (MNs). A number of causative genetic mutations under...

BACKGROUND: Nowadays, due to various inherent properties, graphene-based nanoparticles are widely used in drug delivery research. On the other hand, folate receptors are highly expressed on the surfac...

Background Chromobox protein homolog 7 (CBX7), a member of the Polycomb repressor complex, is a potent epigenetic regulator and gene silencer. Our group has previously reported that CBX7 functions as ...

The tumor microenvironment includes a complex network of immune T-cell subsets that play important roles in colorectal cancer (CRC) progression and are key elements of CRC immunotherapy. T cells devel...

Accurate prediction of the likelihood of recurrence is important in the selection of postoperative treatment for patients with early-stage breast cancer. In this study, we investigated whether deep ...

BACKGROUND: The immunity of patients with lung cancer decreases after treatment; thus, they are easily infected with pathogenic bacteria that causes pulmonary infections. Understanding the distributio...

Aim The present study aimed to investigate healthcare professionals’ perceptions and experiences in caring for cervical cancer patients. The present study was also designed to assess the healthcare pr...

BACKGROUND: Patient navigation is an evidence-based intervention that reduces cancer health disparities by directly addressing the barriers to care for underserved patients with cancer. Variability in...

Background Dysregulation in histone acetylation, a significant epigenetic alteration closely associated with major pathologies including cancer, promotes tumorigenesis, inactivating tumor-suppressor g...

A combined treatment approach that targets both skin tumor cells and macrophages prevents tumor growth in malignant melanoma and squamous cell carcinoma. Malignant melanoma is the most aggressive and ...

Background Long-non-coding RNA PVT1 (lncRNA PVT1) can be used as an oncogenic regulatory non-coding RNA (ncRNA) for many cancers. However, its function and mechanism in breast cancer (BRCA) are still ...

Machine learning (ML) approaches have been used to develop highly accurate and efficient applications in many fields including bio-medical science. However, even with advanced ML techniques, cancer ...

Prostate cancer is a major disease that threatens men’s health. Its rapid progression, easy metastasis, and late castration resistance have brought obstacles to treatment. It is necessary to find new ...

The female pelvis has a complex anatomy, and benign adnexal diseases can present as malignant ovarian masses clinically and radiologically. Between 1 June 2011 and 28 September 2022, we included in th...

Background Whether cytochrome P450 24A1 (CYP24A1) polymorphism is associated with cancer susceptibility, the individual study results are still controversial. Therefore, we performed a comprehensive s...

Background This study aimed to investigate the trends of aggressive care at the end-of-life (EoL) for patients with advanced cancer in Korea and to identify factors affecting such care analyzing natio...

BACKGROUND: Activation and regulation of androgen receptor (AR) signaling and the DNA damage response impact the prostate cancer (PCa) treatment modalities of androgen deprivation therapy (ADT) and ra...

Purpose Pegylated liposomal doxorubicin (PLD)-induced hand-foot syndrome (HFS) frequently lowers the quality of life of ovarian cancer patients. Wrist and ankle cooling, having a limited preventive ef...

[Image: see text] Extremely short half-life therapeutic molecule nitric oxide (NO) plays significant roles in the functioning of various physiological and pathological processes in the human body, whe...

Objective: To investigate the effects of electroacupuncture pre-stimulation on perioperative neurocognitive disorders (PNDs) in patients undergoing colon cancer surgery. Methods: A total of 80 elderly...

Objective To investigate the effect of interferon-γ (IFN-γ) on the immune microenvironment and the polarity of tumor-associated macrophages (TAMs) in stage IA non-small cell lung cancer (NSCLC) and it...

Purpose [^18F]-FDG PET/CT and brain MRI are common approaches to detect metastasis in patients of lung cancer. Current guidelines for the use of PET/CT and MRI in clinical T1-category lung cancer lack...

BACKGROUND: Acute tumour embolism to the popliteal artery resulting in limb-threatening ischemia is a rare complication of neoplastic disease. Generally, tumors embolize to the pulmonary circulation v...

In the online knapsack problem, the goal is to pack items arriving online with different values and weights into a capacity-limited knapsack to maximize the total value of the accepted items. We stu...

Graph contrastive learning (GCL) has recently emerged as a new concept which allows for capitalizing on the strengths of graph neural networks (GNNs) to learn rich representations in a wide variety ...

Multi-task dense scene understanding, which learns a model for multiple dense prediction tasks, has a wide range of application scenarios. Modeling long-range dependency and enhancing cross-task int...

Reinforcement Learning from Human Feedback (RLHF) facilitates the alignment of large language models (LLMs) with human preferences, thereby enhancing the quality of responses generated. A critical c...

Social media plays a central role in shaping public opinion and behavior, yet performing experiments on these platforms and, in particular, on feed algorithms is becoming increasingly challenging. T...

Hyper-spectral imaging has recently gained increasing attention for use in different applications, including agricultural investigation, ground tracking, remote sensing and many other. However, the ...

Task-specific functional MRI (fMRI) images provide excellent modalities for studying the neuronal basis of cognitive processes. We use fMRI data to formulate and solve the problem of deconvolving ta...

The conditional diffusion model has been demonstrated as an efficient tool for learning robot policies, owing to its advancement to accurately model the conditional distribution of policies. The int...

We introduce MelodyFlow, an efficient text-controllable high-fidelity music generation and editing model. It operates on continuous latent representations from a low frame rate 48 kHz stereo variati...

Deep learning has been impressively successful in the last decade in predicting human head poses from monocular images. However, for in-the-wild inputs the research community relies predominantly on...

Continuum and soft robots can positively impact diverse sectors, from biomedical applications to marine and space exploration, thanks to their potential to adaptively interact with unstructured envi...

Multi-variate time series forecasting is an important problem with a wide range of applications. Recent works model the relations between time-series as graphs and have shown that propagating inform...

In the evolving application of medical artificial intelligence, federated learning is notable for its ability to protect training data privacy. Federated learning facilitates collaborative model dev...

The rapid development of Multimodal Large Language Models (MLLMs) is making AI-driven scientific assistants increasingly feasible, with interpreting scientific figures being a crucial task. However,...

Service liquidity across edge-to-cloud or multi-cloud will serve as the cornerstone of the next generation of cloud computing systems (Cloud 2.0). Provided that cloud-based services are predominantl...

We conducted a thorough SLR to better grasp the challenges and possible solutions associated with existing npm security tools. Our goal was to delve into documented experiences and findings. Specifi...

In the context of goal-oriented communications, this paper addresses the achievable rate versus generalization error region of a learning task applied on compressed data. The study focuses on the di...

Participatory design initiatives, especially within the realm of digital civics, are often integrated and co-developed with the very citizens and communities they intend to assist. Digital civics re...

The development of data-driven approaches for solving differential equations has been followed by a plethora of applications in science and engineering across a multitude of disciplines and remains ...

Attracting and retaining a steady stream of new contributors is crucial to ensuring the long-term survival of open-source software (OSS) projects. However, there are two key research gaps regarding ...

In the last twenty years, Structure from Motion (SfM) has been a constant research hotspot in the fields of photogrammetry, computer vision, robotics etc., whereas real-time performance is just a re...

Equations system constructors of hierarchical circuits play a central role in device modeling, nonlinear equations solving, and circuit design automation. However, existing constructors present limi...

Background Since the declaration of COVID-19 as a pandemic in 2020, its main symptoms have primarily affected the respiratory system. However, it also presents other systemic manifestations, including...

Aim Long-haul COVID-19 poses a profound burden to public health. According to the CDC, approximately one in five people who contract COVID-19 have lingering COVID-related symptoms 3 months after testi...

As a novel virus, COVID introduced considerable uncertainty into the daily lives of people all over the globe since late 2019. Relying on twenty-three semi-structured interviews with parents whose c...

The global pandemic due to emergence of COVID 19 has created the unrivaled public health crisis. It has huge morbidity rate never comprehended in the recent decades. Researchers have made many effor...

Since the outbreak of COVID-19 pandemic in 2020, numerous researches and studies have focused on the long-term effects of COVID infection. The Centers for Disease Control (CDC) implemented an addition...

Aim Long-haul COVID-19 poses a profound burden to public health. According to the CDC, approximately one in five people who contract COVID-19 have lingering COVID-related symptoms 3 months after testi...

Aim Long-haul COVID-19 poses a profound burden to public health. According to the CDC, approximately one in five people who contract COVID-19 have lingering COVID-related symptoms 3 months after testi...

More than three years after the start of the COVID-19 pandemic, individuals are frequently reporting multiple COVID-19 infections. However, these reinfections remain poorly understood. Here, we invest...

Purpose This longitudinal study investigated distress rates in patients with advanced ovarian cancer during the COVID-19 pandemic and examined whether time, illness representations, and coping strateg...

Zang et al. use RECOVER EHR data to study Long COVID risk factors and apply mathematical modeling to predict the development of long COVID conditions. They find that severe acute SARS-CoV-2 infection,...

Background Since the declaration of COVID-19 as a pandemic in 2020, its main symptoms have primarily affected the respiratory system. However, it also presents other systemic manifestations, including...

Objective To examine the relationship between physical rehabilitation parameters including an approach to quantifying dosage with hospital outcomes for patients with critical COVID-19. Design Retrospe...

More than three years after the start of the COVID-19 pandemic, individuals are frequently reporting multiple COVID-19 infections. However, these reinfections remain poorly understood. Here, we invest...

Objective To examine the relationship between physical rehabilitation parameters including an approach to quantifying dosage with hospital outcomes for patients with critical COVID-19. Design Retrospe...

Background The emergence of COVID-19 precipitated containment policies (e.g., lockdowns, school closures, etc.). These policies disrupted healthcare, potentially eroding gains for Sustainable Developm...

BACKGROUND: It is unknown if early COVID-19 monoclonal antibody (mAb) therapy can reduce risk of Long COVID. The mAbs amubarvimab/romlusevimab were previously demonstrated to reduce risk of hospitaliz...

BACKGROUND: It is unknown if early COVID-19 monoclonal antibody (mAb) therapy can reduce risk of Long COVID. The mAbs amubarvimab/romlusevimab were previously demonstrated to reduce risk of hospitaliz...

Background The emergence of COVID-19 precipitated containment policies (e.g., lockdowns, school closures, etc.). These policies disrupted healthcare, potentially eroding gains for Sustainable Developm...

Zang et al. use RECOVER EHR data to study Long COVID risk factors and apply mathematical modeling to predict the development of long COVID conditions. They find that severe acute SARS-CoV-2 infection,...

The global pandemic due to emergence of COVID 19 has created the unrivaled public health crisis. It has huge morbidity rate never comprehended in the recent decades. Researchers have made many effor...

Since the outbreak of COVID-19 pandemic in 2020, numerous researches and studies have focused on the long-term effects of COVID infection. The Centers for Disease Control (CDC) implemented an addition...

As a novel virus, COVID introduced considerable uncertainty into the daily lives of people all over the globe since late 2019. Relying on twenty-three semi-structured interviews with parents whose c...

Background There is an urgent need to understand the interplay between SARS-CoV-2 and HIV to inform risk-mitigation approaches for HIV-infected individuals. Objectives We conclude that people living w...

Objectives In 2014, Ontario’s Point-of-Care (POC) test providers were advised to focus efforts on provincially defined priority populations who experience a greater risk of HIV. Our objective was to d...

Background Highly effective, short-course, bedaquiline-containing treatment regimens for multidrug-resistant tuberculosis (MDR-TB) and integrase strand transfer inhibitor (INSTI)-containing fixed dose...

Objectives. To assess changes in minor consent laws for sexually transmitted infection (STI) and HIV testing, treatment, and prevention services in all 50 US states and the District of Columbia from 1...

BACKGROUND: People living with HIV (PLWH) have a higher risk of developing hypertension compared to HIV uninfected individuals. HIV assisted partner services (aPS), where PLWH are assisted by a health...

Background Little is known about the etiology, clinical presentation, management, and outcome of central nervous system (CNS) infections in Indonesia, a country with a high burden of infectious diseas...

Background In the first reported cases of human immunodeficiency virus (HIV) infection, people living with HIV (PLHIV) suffered weight loss, which was an independent predictor of mortality. Highly act...

Background Significant heterogeneity exists among people who use drugs (PWUD). We identify distinct profiles of syringe service program (SSP) clients to (a) evaluate differential risk factors across s...

Background The sensitivity of HIV screening assays often leads to a high rate of false-positive results, requiring retests and confirmatory tests. This study aimed to analyze the capability of signal-...

Introduction Mississippi has one of the highest rates of HIV in the United States but low PrEP uptake. Understanding patterns of PrEP use can improve PrEP initiation and persistence. Methods This is a...

Introduction In 2022, the WHO reported that 29.8 million people around the world were living with HIV (PLHIV) and receiving antiretroviral treatment (ART), including 25‌ 375 people in Gabon (54% of al...

Intravenous administration of the BCG vaccine protects non-human primates with pre-existing SIV infection from tuberculosis. Tuberculosis, caused by Mycobacterium tuberculosis (Mtb), is the most commo...

Background Input from end-users during preclinical phases can support market fit for new HIV prevention technologies. With several long-acting pre-exposure prophylaxis (PrEP) implants in development, ...

INTRODUCTION: Human cathelicidin LL-37 is a salivary antimicrobial peptide (AMP) with broad-spectrum activity against oral diseases, but few studies have assessed its role in children and adolescents ...

In this cohort study, we determined time to blood pressure (BP) control and its predictors among hypertensive PLHIV enrolled in integrated hypertension-HIV care based on the World Health Organization ...

Background Human immunodeficiency virus (HIV) drug prophylaxis, including post-exposure prophylaxis (PEP) and pre-exposure prophylaxis (PrEP), has not yet been generally recognized and accepted by the...

Introduction Globally, the incidence of HIV and syphilis can be reduced by the use of validated point of care tests (POCTs). As part of the WHO PRoSPeRo Network, we aimed to evaluate the performance, ...

The capture-recapture method is a common tool used in epidemiology to estimate the size of “hidden” populations and correct the underascertainment of cases, based on incomplete and overlapping lists o...

In this cohort study, we determined time to blood pressure (BP) control and its predictors among hypertensive PLHIV enrolled in integrated hypertension-HIV care based on the World Health Organization ...

Purpose of Review To explore the intersection of chatbots and HIV prevention and care. Current applications of chatbots in HIV services, the challenges faced, recent advancements, and future research ...

Background and aims Liver-associated complications still frequently lead to mortality in people with HIV (PWH), even though combined antiretroviral treatment (cART) has significantly improved overall ...

Nitrite inhalants (poppers) are associated with HIV transmission and commonly used among young men who have sex with men (YMSM), a group at increased risk for HIV. Significant research gaps exist in u...

Background The elderly bear the highest burden of South Africa’s estimated annual > 10 million influenza cases and > 11,000 influenza-related deaths. Unvaccinated healthcare workers (HCWs) are at high...

Background: Prophylactic strategies are urgently needed for prevention of severe inflammatory responses to respiratory viral infections. Bacterial-host interactions may modify the immune response to v...

STUDY DESIGN Cross-sectional survey. OBJECTIVES To evaluate the annual influenza vaccination coverage rate (IVCR) among community-dwelling individuals with spinal cord injury (SCI). SETTIN...

Purpose Given reduced immunity levels for seasonally occurring respiratory infections and the experience of an unusually early, severe wave of RSV infections during 2021, a preexisting clinician-led r...

Within poultry breeding sites, wild birds are often suspected to transmit pathogens, especially peridomestic species which can act as bridge hosts. In this study, we explored the role o...

BACKGROUND: Influenza is a global health threat to older adults, and the influenza vaccine is the most effective approach to prevent influenza infection. However, influenza vaccination coverage among ...

Background/Aims  To quantify the risk of death among people with vasculitis during the UK 2020 COVID-19 epidemic compared with baseline risk, risk during annual influenza seasons and risk of death in ...

Background Respiratory viral illnesses among children are a prominent cause of morbidity and mortality in the developing world. The aim of this study is to understand the seasonal pattern and surge of...

Background The cytokines play an essential role in acute inflammatory processes, and the IL-17 may be responsible for ambiguous aspects, and the correlation with genetic polymorphisms could improve th...

OBJECTIVE: To study the efficacy and safety of arbidol hydrochloride tablets as a treatment for influenza-like diseases. METHODS: In this multicenter, randomized, controlled, open label study, a total...

Background Previous studies provided some evidence of meteorological factors influence seasonal influenza transmission patterns varying across regions and latitudes. However, research on seasonal infl...

BACKGROUND: The potential benefits of using rapid influenza diagnostic tests (RIDTs) in urgent care facilities for clinical care and prescribing practices are understudied. We compared antiviral and a...

Forecasting influenza in a timely manner aids health organizations and policymakers in adequate preparation and decision making. However, effective influenza forecasting still remains a challenge de...

Aim The aim of this study was to complete a descriptive qualitative investigation of parents’ perceptions of the barriers and facilitators to flu vaccination for pre-school children. Subject and metho...

Forecasting influenza in a timely manner aids health organizations and policymakers in adequate preparation and decision making. However, effective influenza forecasting still remains a challenge de...

BACKGROUND AND AIMS: Patients with glomerulonephritis may have an increased risk of influenza infection and morbidity, but vaccine coverage remained low with little data on acceptance in glomeruloneph...

Forecasting the hospitalizations caused by the Influenza virus is vital for public health planning so that hospitals can be better prepared for an influx of patients. Many forecasting methods have b...

OBJECTIVES: To examine inpatient vaccine delivery across a national sample of children’s hospitals. METHODS: We conducted a retrospective cohort study examining vaccine administration at 49 children’s...

International audience; Studies comparing outcomes of ICU patients admitted for either COVID-19 or seasonal influenza are limited. Our objective was to describe baseline clinical profile...

BACKGROUND: Immunosuppressive therapy (IS) has altered the course of Inflammatory Bowel Disease (IBD). IBD patients are at considerable risk of developing vaccine-preventable illness and are even more...

OBJECTIVE: Influenza virus, which is associated with high level of morbidity and mortality, has been recently considered a public health concern; however, the methods of choice to control and treat it...

BACKGROUND: In recent years, accumulating evidences have revealed that influenza A virus (IAV) infections induce significant differential expression of host long noncoding RNAs (lncRNAs), some of whic...

Background Infection with Helicobacter pylori as the cause of gastric cancer is a global public health concern. In addition to protecting germs from antibiotics, biofilms reduce the efficacy of H. pyl...

Background Enterocytozoon bieneusi, Encephalitozoon spp., Cryptosporidium spp., and Giardia duodenalis (G. intestinalis) are enteric pathogens that cause diarrhea in pigs. This study aimed to determin...

Resistance mechanisms are a shelter for Acinetobacter baumannii to adapt to our environment which causes difficulty for the infections to be treated and WHO declares this organism on the top of pathog...

Background Allergic rhinitis (AR) is characterized by airway inflammation in nasal mucosa from inhaled allergens and interleukin (IL)-33 is the potent inducer of Th2 inflammation in allergic nasal epi...

Background The ascomycetous heterothallic yeast Wickerhamomyces anomalus (WA) has received considerable attention and has been widely reported in the winemaking industry for its distinctive physiologi...

Since the emergence of SARS-CoV-2 in December 2019, more than 12,000 mutations in the virus have been identified. These could cause changes in viral characteristics and directly impact global public h...

Background Candidatus Ornithobacterium hominis ( O. hominis ), which was identified in nasopharyngeal swabs from Egypt, has been associated with respiratory disorders in humans. O. hominis , a recentl...

Background The gut microbiota plays a crucial role in regulating the host’s immune responses during aging, which was characterized by a different abundance of bacteria in several age groups. Main body...

Plant growth promoting microbe assisted phytoremediation is considered a more effective approach to rehabilitation than the single use of plants, but underlying mechanism is still unclear. In this stu...

Background Co-infection with other pathogens in coronavirus disease 2019 (COVID-19) patients exacerbates disease severity and impacts patient prognosis. Clarifying the exact pathogens co-infected with...

Background The microbiota in fish external mucus is mainly known for having a role in homeostasis and protection against pathogens, but recent evidence suggests it is also involved in the host-specifi...

In this study fungal strains were investigated, which had been isolated from eggs of the cereal cyst nematode Heterodera filipjevi , and roots of Microthlaspi perfoliatum ( Brassicaceae ). The morphol...

Background Brucellosis is an economically devastating animal disease and has public health concern. Serological methods such as Rose Bengal Plate Test (RBPT), Complement Fixation Test (CFT), and Indir...

Chrysomyxa rusts cause significant damage to spruce in both natural forests and plantations. Particularly, Three Chrysomyxa species, Chrysomyxa deformans , Chrysomyxa qilianensis , and Chrysomyxa rhod...

Background Circadian rhythms, observed across all domains of life, enable organisms to anticipate and prepare for diel changes in environmental conditions. In bacteria, a circadian clock mechanism has...

Various eco-friendly techniques are being researched for synthesizing ZnO-NPs, known for their bioactivity. This study aimed at biosynthesizing ZnO-NPs using Streptomyces baarnensis MH-133, characteri...

Purpose Microbial resources are abundant in fermented grains of the Chinese Fen-flavor Baijiu , which is closely related to the quality of Baijiu . The purpose of this study was to investigate the mic...

Background COVID-19 emerged in late 2019 and has occasioned more than 765 millions cumulative cases and 6.9 millions of deaths globally. Notably, around 70% of patients with severe COVID-19 are men. T...

Background Infection with Helicobacter pylori as the cause of gastric cancer is a global public health concern. In addition to protecting germs from antibiotics, biofilms reduce the efficacy of H. pyl...

Background Drought stress is currently the primary abiotic stress factor for crop loss worldwide. Although drought stress reduces the crop yield significantly, species and genotypes differ in their st...

Background Uterine infections, primarily caused by bacterial pathogens, pose a significant problem for dairy farmers worldwide, leading to poor reproductive performance and economic losses. However, t...

Background Hyaluronic acid (HA) has gained significant attention due to its unique physical, chemical, and biological properties, making it widely used in various industries. This study aimed to scree...

INTRODUCTION: Functional neurological disorder (FND) is a common cause of referral to neurology services. FND has been shown to lead to significant healthcare resource use and is associated with signi...

BACKGROUND AND AIMS: Guillain-Barré syndrome (GBS) is usually triggered by an infection. Vaccination is mentioned as a possible trigger in a small number of GBS cases. The aim of this study was to not...

BACKGROUND: Myelin oligodendrocyte glycoprotein-associated disorders (MOGAD) is an autoimmune central nervous system disease. Antigen-specific immune tolerance using nanoparticles such as Polylactic-c...

BACKGROUND: Idiopathic intracranial hypertension (IIH) is a neurometabolic condition severely impacting the quality of life of people living with IIH (PwIIH). Most PwIIH are overweight or live with ob...

Parental input is considered a key predictor of language achievement during the first years of life, yet relatively few studies have assessed the effects of parental language input and parent–infant i...

BACKGROUND AND PURPOSE: Surgical clipping and endovascular treatment are commonly used in patients with unruptured intracranial aneurysms. We compared the safety and efficacy of the 2 treatments in a ...

INTRODUCTION: It is widely demonstrated that high frequency (HF) repetitive transcranial magnetic stimulation (rTMS) has facilitative effects and is therefore capable to inducing changes in motor resp...

BACKGROUND: The UK Medicines Health products Regulation Agency instructs that valproate prescriptions should be restricted in women of childbearing age to those consenting to the Pregnancy Prevention ...

INTRODUCTION: It is widely demonstrated that high frequency (HF) repetitive transcranial magnetic stimulation (rTMS) has facilitative effects and is therefore capable to inducing changes in motor resp...

BACKGROUND: Middle meningeal artery embolization is an emerging treatment option for chronic subdural hematomas. PURPOSE: Our aim was to assess outcomes following middle meningeal artery embolization ...

OBJECTIVE: This study was to investigate the therapeutic effect of high-frequency repetitive magnetic stimulation (HF-rMS) at the sacrum for chronic constipation in Parkinson’s patients (PD). MATERIAL...

BACKGROUND: The habenula is a major regulator of serotonergic neurons in the dorsal raphe, and thus of brain state. The functional connectivity between these regions is incompletely characterized. Her...

Acute cerebellar ataxia (ACA) is a self-limited syndrome that is frequently post-infectious, most commonly following Varicella infection having an autoimmune mechanism. ACA is the commonest cause of c...

BACKGROUND: Nationally representative studies evaluating the impact of the COVID-19 pandemic on haemorrhagic stroke outcomes are lacking. METHODS: In this pooled cross-sectional analysis, we identifie...

The macaque middle temporal (MT) area is well known for its visual motion selectivity and relevance to motion perception, but the possibility of it also reflecting higher-level cognitive functions has...

Despite the indispensable role that astrocytes play in the neurovascular unit, few studies have investigated the functional impact of astrocyte signaling in cognitive decline and dementia related to v...

BACKGROUND: Both Impulse-control disorders and related behaviours (ICD-RB) and restless leg syndrome (RLS) are relatively common in patients with Parkinson’s disease, but little is known are they rela...

In this narrative review, we examine biological processes linking psychological stress and cognition, with a focus on how psychological stress can activate multiple neurobiological mechanisms that dri...

Background There are increasing reports of cases of Guillain-Barré syndrome (GBS), as an adverse event of an immune checkpoint inhibitor (ICI) but postmarket data on the incidence of this remains scar...

The Slack channel (KCNT1, Slo2.2) is a sodium-activated and chloride-activated potassium channel that regulates heart rate and maintains the normal excitability of the nervous system. Despite intense ...

OBJECTIVE: The goal of this study was to determine the base rates of failing proposed embedded validity indicators (EVIs) for the National Institutes of Health Toolbox Cognition Battery (NIHTB-CB) in ...

BACKGROUND AND PURPOSE: The detection rate of premortem MR imaging endolymphatic hydrops is lower than that of postmortem endolymphatic hydrops in Ménière disease, indicating that current MR imaging t...

Deep Brain Stimulation (DBS) is a successful and encouraging way of treating abnormal movement diseases, such as Parkinson’s Disease (PD). The success of the surgical procedure depends ...

BACKGROUND: Continuous, subcutaneous (SC) levodopa/carbidopa infusion with ND0612 is under development as a treatment for patients with Parkinson's disease (PD) and motor fluctuations. OBJECTIVE: Eval...

International audience; Objective: Survival of patients with monogenic Parkinson's disease may depend on the causative genes associated with the disease. In this study, we compare surviv...

International audience; Parkinson's disease is a neurodegenerative disease that affects more than 6.1 million people worldwide. In the clinical routine, the main tool to diagnose and mon...

One of the most catastrophic neurological disorders worldwide is Parkinson's Disease. Along with it, the treatment is complicated and abundantly expensive. The only effective action to control the p...

International audience; Background: Parkinson's disease (PD) is characterized by a severe loss of the dopaminergic (DA) neurons in the substantia nigra pars compacta (SNpc). Perturbation...

BACKGROUND: Dystonia is an understudied motor feature of Parkinson's disease (PD). Although considerable efforts have focused on brain oscillations related to the cardinal symptoms of PD, whether dyst...

PURPOSE: To report convergence insufficiency in a patient with Parkinson's’ disease stimulated by turning on the deep brain stimulator. OBSERVATIONS: 72-year-old male with Parkinson's disease and hype...

Flexible Endoscopic Evaluation of Swallowing (FEES) is one of two diagnostic gold standards for pharyngeal dysphagia in Parkinson's disease (PD), however, validated global outcome measures at the pati...

Background Traditionally, functional neurosurgery relied in stereotactic atlases and intraoperative micro-registration in awake patients for electrode placement in Parkinson’s disease. Cumulative expe...

Limited accessibility to neurological care leads to underdiagnosed Parkinson's Disease (PD), preventing early intervention. Existing AI-based PD detection methods primarily focus on unimodal analysi...

Background and objectives: Dynamic handwriting analysis, due to its non-invasive and readily accessible nature, has recently emerged as a vital adjunctive method for the early diagnosis of Parkinson...

Intraneuronal accumulation of aggregated α-synuclein is a pathological hallmark of Parkinson’s disease. Therefore, mechanisms capable of promoting α-synuclein deposition bear important pathogenetic im...

INTRODUCTION: Given the rapidly aging population in both the United States and Mexico, rates of Parkinson's disease (PD) are likely to rise in both countries, suggesting that the number of individuals...

Bursts of beta frequency band activity in the basal ganglia of patients with Parkinson's disease (PD) are associated with impaired motor performance. Here we test in human adults whether small variati...

Background Clinical trials have provided evidence that transplants of dopaminergic precursors, which may be replaced by new in vitro stem cell sources, can integrate into the host tissue, and alleviat...

International audience; Parkinson's disease (PD) and the parkinsonian variant of Multiple System Atrophy (MSA-P) are two neurodegenerative diseases which share similar clinical features,...

In this paper, we evaluate the contribution of different handwriting modalities to the diagnosis of Parkinson's disease. We analyse on-surface movement, in-air movement and pressure exerted on the t...

WCNR, 11th World Congress for Neurorehabilitation, Lyon, FRANCE, 07-/10/2020 - 11/10/2020; 1.Question: Patients with Parkinson disease (PD) report difficulties walking while performing a...

BACKGROUND: Parkinson's disease (PD) is a neurodegenerative disorder with a significant immune component, as demonstrated by changes in immune biomarkers in patients' biofluids. However, which specifi...

Parkinson's disease (PD) is a neurodegenerative disorder anatomically characterized by a progressive loss of dopaminergic neurons in the substantia nigra compacta (SNpc). Much less known, yet clinical...

BACKGROUND: The most common genetic risk factor for Parkinson's disease known is a damaging variant in the GBA1 gene. The entire GBA1 gene has rarely been studied in a large cohort from a single popul...

Binary neutron star (BNS) mergers can be sources of ultrahigh-energy (UHE) cosmic rays and potential emitters of UHE neutrinos. The upcoming and current radio neutrino detectors like the Giant Radio...

We report on high-sensitivity neutral hydrogen observations toward the gas-rich interacting galaxies NGC 3395/3396 with the Five-hundred-meter Aperture Spherical radio Telescope (FAST). Compared to ...

Self-Interacting Dark Matter models can successfully explain dark matter (DM) production through interactions confined within the dark sector. However, they often lack measurable experimental signal...

A new model for dark matter is put forward which consists of uniform droplets of Bose Einstein condensate. In this model, structure forms rapidly, shortly after the hot big bang plasma de-ionises. T...

Precise and accurate mass and radius measurements of evolved stars are crucial to calibrating stellar models. Stars in detached eclipsing binaries (EBs) are excellent potential calibrators because t...

We use the high-resolution HR-DEMNUni simulations to compute cross-correlations of the Cosmic Neutrino Background C$_{\nu}$B with other observables, namely: cold dark matter density, effective weak ...

We combined a principal component analysis (PCA) and spectroscopy to investigate the origin of the soft excess in narrow-line Seyfert 1 galaxy Ark 564 with XMM-Newton observations over a period of t...

We summarize our exploratory investigation into whether Machine Learning (ML) techniques applied to publicly available professional text can substantially augment strategic planning for astronomy. W...

White dwarf atmospheres are frequently polluted by material from their own planetary systems. Absorption features from Ca, Mg, Fe and other elements can provide unique insights into the provenance o...

We investigate the impact of using multipoint p-T profiles of varying complexity on the retrieval of synthetically generated hot Jupiter transmission spectra modelled after state-of-the-art observat...

Gravitational lensing offers a powerful tool for exploring the matter distribution in the Universe. Thanks to their low frequencies and phase coherence, gravitational waves (GWs) allow for the obser...

In the host galaxies of radio AGN, kinematically disturbed gas due to jet-driven feedback is a widely observed phenomenon. Simulations predict that the impact of jets on the surrounding gas changes ...

The cores of pulsars are expected to become superconducting soon after birth. The transition to type-II superconductivity is associated with the bunching of magnetic field lines into discrete superc...

Within the RoadMap project we investigated the microphysical aspects of particle collisions during saltation on the Martian surface in laboratory experiments. Following the size distribution of ejec...

This study presents a systematic approach to optimize the scheduling of exoplanet observations using the James Webb Space Telescope (JWST), focusing on targets discovered by the Transiting Exoplanet...

A key scientific goal of exoplanet surveys is to characterize the underlying population of planets in the local galaxy. In particular, the properties of accreting protoplanets can inform the rates a...

The Dark Energy Spectroscopic Instrument (DESI) Peculiar Velocity Survey aims to measure the peculiar velocities of early and late type galaxies within the DESI footprint using both the Fundamental ...

With recent missions such as advanced space-based observatories like the Solar Dynamics Observatory (SDO) and Parker Solar Probe, and ground-based telescopes like the Daniel K. Inouye Solar Telescop...

Primordial gravitational waves from the very early stages of the universe, such as inflation or bounce processes, are an irreducible cosmological source of the stochastic gravitational wave backgrou...

We perform $3+1$ relativistic numerical simulations to study primordial black hole (PBH) formation from the collapse of adiabatic super-horizon non-spherical perturbations generated from curvature f...

Growing observational evidence suggests that enhanced mass loss from the progenitors of core-collapse supernovae (SNe) is common during $\sim1$ yr preceding the explosion, creating an optically thic...

The galaxy cluster Abell 496 has been extensively studied in the past for the clear sloshing motion of the hot gas on large scales, but the interplay between the central radio galaxy and the surroun...

Background Uroliths are stones formed in the urinary tract. Analysis of stones helps to identify risk factors for their development and prevention of recurrence. Standard stone analysis using modern t...

BACKGROUND: Under the restriction of social activities during the coronavirus disease 2019 (COVID-19) pandemic, there was concern about the loss of muscle mass due to a decrease in physical activity f...

BACKGROUND: Acarbose slows down the intestinal absorption of carbohydrates, but its effects on the secretion of incretins are still poorly known. This study aimed to examine the effects of single-dose...

Background This study aimed to compare patient experiences during bronchoscopy procedures using either topical anesthesia (TA) or monitored anesthesia care (MA). The goal was to identify circumstances...

INTRODUCTION: Pre-eclampsia (PE) affects about 5% of Chinese pregnant women and is a major cause of maternal and perinatal morbidity and mortality. The first trimester screening model developed by the...

Background COVID-19 increases the risk of acute ischemic stroke. The objective of this study is to identify the risk factors, comorbidities, and outcomes in COVID-19 patients with acute ischemic strok...

INTRODUCTION: Uncontrolled blood pressure is one of the main risk factors for cardiovascular disease and death in Low-income and middle-income countries. Improvements to medication adherence and lifes...

Purpose: Suicidal ideation and attempts in youth are a growing health concern, and more data are needed regarding their biological underpinnings. Asthma is a common chronic inflammatory disorder in yo...

BACKGROUND: Delirium is an underdiagnosed condition and this may be related, among other causes, to the incorrect use of assessment tools due to lack of knowledge about cognitive assessment and lack o...

The motor impairments of cerebral palsy (CP) are typically accompanied by subsequent musculoskeletal issues, seizures, and abnormalities of sensation, intelligence, communication, and behaviour. These...

High temperature geothermal projects for electricity production are in France mostly localized in the basement of basins linked to the West European Rifting event. The basement of these...

Background The incidence of Total Shoulder Arthroplasty (TSA) and Reverse Total Shoulder Arthroplasty (RTSA) is constantly increasing. As a result, the interest in post-surgical rehabilitation has gro...

International audience; The direction of the association between mental health and adiposity is poorly understood. Our objective was to empirically examine this link in a UK study. This ...

OBJECTIVE: Left ventricular (LV) systolic synchrony is defined as simultaneous activation of corresponding cardiac segments. Impaired synchrony has some adverse cardiovascular effects, such as LV dysf...

Background: Insomnia is associated with several adverse health outcomes. Small clinical studies have suggested that an inferior nutrition status is a potential explanation, but to our knowledge, this ...

BACKGROUND: The Shock Index Creatinine (SIC) scoring is a recently developed tool for risk stratification patients. These updated scoring was already used in ST-Elevation Myocardial Infarction (STEMI)...

OBJECTIVES: This study aimed to assess the coverage and explore enablers and challenges in implementation of direct benefit transfer (DBT) cash incentive scheme for patients with tuberculosis (TB). DE...

BACKGROUND: The clinical endoscopic phenotypes of gastroesophageal reflux disease (GERD) are classified as Barrett's esophagus (BE), erosive esophagitis (EE) and non-erosive gastroesophageal reflux di...

Background Smoking is a significant public health problem, and there is a scarcity of documents regarding its severity, particularly in developing countries. This study aimed to determine factors rela...

Background Over the past years, Mozambique has implemented several initiatives to ensure equitable coverage to health care services. While there have been some achievements in health care coverage at ...

Developing a system to detect online offensive language is very important to the health and the security of online users. Studies have shown that cyberhate, online harassment and other misuses of te...

Background Liver is a complex, highly vascular organ, where anatomical variations are the norm. This study aimed to analyze all the three hepatic vascular anatomical variations in a single study which...

The present study investigated the impact of dietary inclusion of olive cakes (OC) with or without Saccharomyces cerevisiae (SC) and citric acid (CA) on growth, digestive function, thyroid activity, a...

Background Anaplastic thyroid carcinoma(ATC) is a rare pathological type of thyroid malignancy. Primary squamous cell carcinoma of thyroid(PSCCT) is now considered as a subtype of ATC, hereinafter ref...

Objectives To study the relationship between the ablation range and applied energy of laser ablation (LA) and microwave ablation (MWA) in papillary thyroid microcarcinoma (PTMC). Methods A total of 20...

Introduction Atezolizumab, carboplatin, and etoposide (ACE) therapy is a standard of care for extensive-disease small cell lung cancer (SCLC); however, its safety data are scarce, limiting generalizat...